Electrocatalysis-Enabled Stereoselective Synthesis of Monofluoroalkenes via Hydrodefluorination of gem-Difluoroakenes

Xiaoying Wang; Jiaxi Cai; Haixia Song; Le Liu; Xin Hua Duan; Mingyou Hu

doi:10.1021/acs.orglett.4c00112

Electrocatalysis-Enabled Stereoselective Synthesis of Monofluoroalkenes via Hydrodefluorination of gem-Difluoroakenes

Xiaoying Wang
, Jiaxi Cai
, Haixia Song
, Le Liu
, Xin Hua Duan
, Mingyou Hu

化学学院

Xi'an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

摘要

We report a simple and economical method to synthesize monofluoroalkenes via the electrochemical hydrodefluorination of gem-difluoroalkenes. This reaction proceeds efficiently at room temperature, eliminating the requirement for a costly transition metal catalyst, ligand, and external reducing agent. The monofluoroalkene products can be obtained in medium to good yields and up to 99:1 E/Z selectivity. The reaction is easily scalable to gram scale.

源语言	英语
页（从-至）	1635-1639
页数	5
期刊	Organic Letters
卷	26
期	8
DOI	https://doi.org/10.1021/acs.orglett.4c00112
出版状态	已出版 - 1 3月 2024

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10.1021/acs.orglett.4c00112

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title = "Electrocatalysis-Enabled Stereoselective Synthesis of Monofluoroalkenes via Hydrodefluorination of gem-Difluoroakenes",

abstract = "We report a simple and economical method to synthesize monofluoroalkenes via the electrochemical hydrodefluorination of gem-difluoroalkenes. This reaction proceeds efficiently at room temperature, eliminating the requirement for a costly transition metal catalyst, ligand, and external reducing agent. The monofluoroalkene products can be obtained in medium to good yields and up to 99:1 E/Z selectivity. The reaction is easily scalable to gram scale.",

author = "Xiaoying Wang and Jiaxi Cai and Haixia Song and Le Liu and Duan, \{Xin Hua\} and Mingyou Hu",

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doi = "10.1021/acs.orglett.4c00112",

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T1 - Electrocatalysis-Enabled Stereoselective Synthesis of Monofluoroalkenes via Hydrodefluorination of gem-Difluoroakenes

AU - Wang, Xiaoying

AU - Cai, Jiaxi

AU - Song, Haixia

AU - Liu, Le

AU - Duan, Xin Hua

AU - Hu, Mingyou

PY - 2024/3/1

Y1 - 2024/3/1

N2 - We report a simple and economical method to synthesize monofluoroalkenes via the electrochemical hydrodefluorination of gem-difluoroalkenes. This reaction proceeds efficiently at room temperature, eliminating the requirement for a costly transition metal catalyst, ligand, and external reducing agent. The monofluoroalkene products can be obtained in medium to good yields and up to 99:1 E/Z selectivity. The reaction is easily scalable to gram scale.

AB - We report a simple and economical method to synthesize monofluoroalkenes via the electrochemical hydrodefluorination of gem-difluoroalkenes. This reaction proceeds efficiently at room temperature, eliminating the requirement for a costly transition metal catalyst, ligand, and external reducing agent. The monofluoroalkene products can be obtained in medium to good yields and up to 99:1 E/Z selectivity. The reaction is easily scalable to gram scale.

UR - https://www.scopus.com/pages/publications/85186088025

U2 - 10.1021/acs.orglett.4c00112

DO - 10.1021/acs.orglett.4c00112

M3 - 文章

C2 - 38373216

AN - SCOPUS:85186088025

SN - 1523-7060

VL - 26

SP - 1635

EP - 1639

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

Electrocatalysis-Enabled Stereoselective Synthesis of Monofluoroalkenes via Hydrodefluorination of gem-Difluoroakenes

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