Effect of Intestinal Function-recovering Decoction on the bacterial and endotoxin translocation as well as MDA and SOD in serum of rats with multiple organ dysfunction syndrome

Objective: To investigate the effect of Intestinal Function-recovering Decoction on the bacteria and endotoxin translocation and the content of malondialdehyde (MDA) and superoxide dismutase (SOD) in serum of rats with multiple organ dysfunction syndrome (MODS). Methods: Fifty-seven SD rats were divided into four groups randomly: control group, MODS group, decoction group and ampicillin group. We detected the content of endotoxin in the peripheral vein, portal vein and ileum. Bacterial translocation, change of ileum mucous membrane in pathomorphology and the contents of MDA, SOD, ALT, AST, Cr and BUN in serum in each group were also examined. Results: The hepatic and renal function and ileum mucous membranes were significantly damaged in MODS group, decoction group and ampicillin group. Compared with those in MODS group, serum MDA, ALT, AST, Cr, BUN and endotoxin in the peripheral vein, portal vein and ileum in decoction group were significantly lower (P<0.01), and serum SOD was all higher (P<0.01). However, no significant difference was shown between ampicillin group and MODS group (P>0.01). It exhibited a negative correlation between serum MDA and SOD in MODS group and ampicillin group (P<0.01). Decoction group and ampicillin group had lower bacterial translocation than MODS group, but with no significant difference. Conclusion: The decoction can inhibit bacterial and endotoxin translocation and oxidant/antioxidant imbalance.