TY - JOUR
T1 - Dynamics and Stability of a Fractional-Order Tumor–Immune Interaction Model with B-D Functional Response and Immunotherapy
AU - Feng, Xiaozhou
AU - Liu, Mengyan
AU - Jiang, Yaolin
AU - Li, Dongping
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/2
Y1 - 2023/2
N2 - In this paper, we investigate a fractional-order tumor–immune interaction model with B-D function item and immunotherapy. First, the existence, uniqueness and nonnegativity of the solutions of the model are established. Second, the local and global asymptotic stability of some tumor-free equilibrium points and a unique positive equilibrium point are obtained. Finally, we use numerical simulation method to visualize and verify the theoretical conclusions. It is known that the fractional-order parameter (Formula presented.) has a stabilization effect, and the tumor cells can be destroyed or controlled by using immunotherapy.
AB - In this paper, we investigate a fractional-order tumor–immune interaction model with B-D function item and immunotherapy. First, the existence, uniqueness and nonnegativity of the solutions of the model are established. Second, the local and global asymptotic stability of some tumor-free equilibrium points and a unique positive equilibrium point are obtained. Finally, we use numerical simulation method to visualize and verify the theoretical conclusions. It is known that the fractional-order parameter (Formula presented.) has a stabilization effect, and the tumor cells can be destroyed or controlled by using immunotherapy.
KW - fractional-order model
KW - numerical simulations
KW - stability
KW - tumor-free equilibrium
UR - https://www.scopus.com/pages/publications/85148863770
U2 - 10.3390/fractalfract7020200
DO - 10.3390/fractalfract7020200
M3 - 文章
AN - SCOPUS:85148863770
SN - 2504-3110
VL - 7
JO - Fractal and Fractional
JF - Fractal and Fractional
IS - 2
M1 - 200
ER -