Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

Minghui Zan; Junjie Li; Shizhong Luo; Zhishen Ge

doi:10.1039/c4cc03120b

Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

Minghui Zan
, Junjie Li
, Shizhong Luo
, Zhishen Ge

University of Science and Technology of China
Anhui Normal University

科研成果: 期刊稿件 › 文章 › 同行评审

92 引用（Scopus）

摘要

The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

源语言	英语
页（从-至）	7824-7827
页数	4
期刊	Chemical Communications
卷	50
期	58
DOI	https://doi.org/10.1039/c4cc03120b
出版状态	已出版 - 24 6月 2014
已对外发布	是

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abstract = "The polymeric nanogels were constructed via host{\textendash}guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.",

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AU - Zan, Minghui

AU - Li, Junjie

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AU - Ge, Zhishen

PY - 2014/6/24

Y1 - 2014/6/24

N2 - The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

AB - The polymeric nanogels were constructed via host–guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.

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U2 - 10.1039/c4cc03120b

DO - 10.1039/c4cc03120b

M3 - 文章

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JO - Chemical Communications

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Dual pH-triggered multistage drug delivery systems based on host–guest interaction-associated polymeric nanogels

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