DDX47 promotes cell proliferation and migration in lung adenocarcinoma

Yang Chen; Lizhong Zeng; Wei Wang; Jingyan Yuan; Ruiying Sun; Shuanying Yang

doi:10.1016/j.prp.2022.153921

DDX47 promotes cell proliferation and migration in lung adenocarcinoma

Yang Chen
, Lizhong Zeng
, Wei Wang
, Jingyan Yuan
, Ruiying Sun
, Shuanying Yang

The Second Affiliated Hospital of Xi'an Jiaotong University
The First Affiliated Hospital of Xi’an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

3 引用（Scopus）

摘要

This study aimed to investigate the role of DEAD-box helicase 47 (DDX47) in lung adenocarcinoma (LUAD). Our results demonstrated that DDX47 was highly expressed in LUAD tissues, and its high expression predicted a poor prognosis. Bioinformatics analysis indicated that DDX47 involved RNA processing and cell division. Furthermore, knockdown of DDX47 reduced cell proliferation and migration in vitro. In sum, our data confirmed the cancer-promoting effect of DDX47.

源语言	英语
文章编号	153921
期刊	Pathology Research and Practice
卷	234
DOI	https://doi.org/10.1016/j.prp.2022.153921
出版状态	已出版 - 6月 2022
已对外发布	是

联合国可持续发展目标

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可持续发展目标 3 良好健康与福祉

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10.1016/j.prp.2022.153921

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title = "DDX47 promotes cell proliferation and migration in lung adenocarcinoma",

abstract = "This study aimed to investigate the role of DEAD-box helicase 47 (DDX47) in lung adenocarcinoma (LUAD). Our results demonstrated that DDX47 was highly expressed in LUAD tissues, and its high expression predicted a poor prognosis. Bioinformatics analysis indicated that DDX47 involved RNA processing and cell division. Furthermore, knockdown of DDX47 reduced cell proliferation and migration in vitro. In sum, our data confirmed the cancer-promoting effect of DDX47.",

keywords = "DDX47, Lung adenocarcinoma, Migration, Proliferation",

author = "Yang Chen and Lizhong Zeng and Wei Wang and Jingyan Yuan and Ruiying Sun and Shuanying Yang",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier GmbH",

year = "2022",

month = jun,

doi = "10.1016/j.prp.2022.153921",

language = "英语",

volume = "234",

journal = "Pathology Research and Practice",

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TY - JOUR

T1 - DDX47 promotes cell proliferation and migration in lung adenocarcinoma

AU - Chen, Yang

AU - Zeng, Lizhong

AU - Wang, Wei

AU - Yuan, Jingyan

AU - Sun, Ruiying

AU - Yang, Shuanying

PY - 2022/6

Y1 - 2022/6

N2 - This study aimed to investigate the role of DEAD-box helicase 47 (DDX47) in lung adenocarcinoma (LUAD). Our results demonstrated that DDX47 was highly expressed in LUAD tissues, and its high expression predicted a poor prognosis. Bioinformatics analysis indicated that DDX47 involved RNA processing and cell division. Furthermore, knockdown of DDX47 reduced cell proliferation and migration in vitro. In sum, our data confirmed the cancer-promoting effect of DDX47.

AB - This study aimed to investigate the role of DEAD-box helicase 47 (DDX47) in lung adenocarcinoma (LUAD). Our results demonstrated that DDX47 was highly expressed in LUAD tissues, and its high expression predicted a poor prognosis. Bioinformatics analysis indicated that DDX47 involved RNA processing and cell division. Furthermore, knockdown of DDX47 reduced cell proliferation and migration in vitro. In sum, our data confirmed the cancer-promoting effect of DDX47.

KW - DDX47

KW - Lung adenocarcinoma

KW - Migration

KW - Proliferation

UR - https://www.scopus.com/pages/publications/85129783446

U2 - 10.1016/j.prp.2022.153921

DO - 10.1016/j.prp.2022.153921

M3 - 文章

C2 - 35490652

AN - SCOPUS:85129783446

SN - 0344-0338

VL - 234

JO - Pathology Research and Practice

JF - Pathology Research and Practice

M1 - 153921

ER -

DDX47 promotes cell proliferation and migration in lung adenocarcinoma

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联合国可持续发展目标

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