Correlation between LDL cholesterol/HDL cholesterol ratio and severity of coronary disease in obese and non-obese patients with acute coronary syndrome

Objective: To investigate the correlation between low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio and severity of coronary disease in obese and non-obese patients with acute coronary syndrome (ACS). Methods: Totally 394 patients with ACS were divided into two groups: obesity with ACS [n=78, BMI≥28 kg/m² or WHR>0.9 (male) or >0.85 (female)] and non-obesity with ACS (n=316). Another 101 healthy individuals served as controls. According to results of coronary angiography, Gensini scores were calculated to quantize the severity of coronary arterial stenosis, and blood lipid indices were determined. Gensini scores and blood lipid indices were compared between the first two groups, and linear correlation analysis was made of Gensini scores and blood lipid indices. Results: LDL-C/HDL-C ratio was positively correlated with Gensini scores in obese patients with ACS. Gensini scores, total cholesterol (TC) and ApoB were significantly higher in high LDL-C/HDL-C value sub-group than in low LDL-C/HDL-C value sub-group (P<0.01) while ApoA1 was significantly lower in high LDL-C/HDL-C value sub-group than in low LDL-C/HDL-C value sub-group (P<0.05). There was a significant difference in Gensini scores between the low LDL-C/HDL-C value sub-group and the high-value sub-group (t=-3.511, P<0.05). However, Gesini score was not significantly correlated with LDL-C in obese patients with ACS (t=-0.706, P>0.05). Conclusion: Gensini score in obese patients with ACS is significantly correlated with LDL-C/HDL-C ratio. LDL-C/HDL-C ratio may be a better index to estimate the severity of coronary lesion than LDL-C.