Correlation between clinical characteristics of schizophrenia and gene polymorphisms of glial cell line-derived neurotrophic factor

Objective: To explore the correlation between gene polymorphisms of glial cell line-derived neurotrophic factor (GDNF) and clinical characteristics of schizophrenia. Methods: Altogether 303 schizophrenia patients and 300 healthy controls recruited were consistent with the inclusion and exclusion criteria. Their clinical data and blood samples were collected. The gene polymorphisms of GDNF were determined with PCR-RFLP technique. We selected 2 SNP loci of GDNF gene, rs2973050 and rs2910702. SPSS13.0 software was used to make statistical analysis. Results: Circled digit one Rs2910702 of GDNF in the patient group was deviated from Hardy-Weinberg's equilibrium (χ² = 24.983, P = 0.000). Circled digit two The allele frequency of GDNF had no significant difference in distribution between the patient group and the control group (P > 0.05), but the genotype frequency differed significantly in distribution between the cases and controls (P < 0.05). Circled digit three GDNF genotypes were not significantly correlated with the clinical typing of schizophrenia or factors in PANSS scale. Conclusion: Rs2973050 genotype C/C and rs2910702 genotype G/G may be related to the occurrence of schizophrenia; therefore, they are the risk genotypes of schizophrenia.