Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters

Mingyou Hu; Qiqiang Xie; Xinjin Li; Chuanfa Ni; Jinbo Hu

doi:10.1002/cjoc.201600004

Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters

Mingyou Hu
, Qiqiang Xie
, Xinjin Li
, Chuanfa Ni
, Jinbo Hu

CAS - Shanghai Institute of Organic Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

14 引用（Scopus）

摘要

A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D₂O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.

源语言	英语
页（从-至）	469-472
页数	4
期刊	Chinese Journal of Chemistry
卷	34
期	5
DOI	https://doi.org/10.1002/cjoc.201600004
出版状态	已出版 - 1 5月 2016
已对外发布	是

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title = "Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters",

abstract = "A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D2O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99\% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.",

keywords = "copper, deuterium, diazo compounds, trifluoromethylation",

author = "Mingyou Hu and Qiqiang Xie and Xinjin Li and Chuanfa Ni and Jinbo Hu",

note = "Publisher Copyright: {\textcopyright} 2016 SIOC, CAS, Shanghai \& Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2016",

month = may,

day = "1",

doi = "10.1002/cjoc.201600004",

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TY - JOUR

T1 - Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters

AU - Hu, Mingyou

AU - Xie, Qiqiang

AU - Li, Xinjin

AU - Ni, Chuanfa

AU - Hu, Jinbo

PY - 2016/5/1

Y1 - 2016/5/1

N2 - A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D2O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.

AB - A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D2O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.

KW - copper

KW - deuterium

KW - diazo compounds

KW - trifluoromethylation

UR - https://www.scopus.com/pages/publications/84964469228

U2 - 10.1002/cjoc.201600004

DO - 10.1002/cjoc.201600004

M3 - 文章

AN - SCOPUS:84964469228

SN - 1001-604X

VL - 34

SP - 469

EP - 472

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 5

ER -

Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters

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