Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed α-arylation/alkylation sequence

Pengfei Li; Stephen L. Buchwald

doi:10.1002/anie.201102401

Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed α-arylation/alkylation sequence

Pengfei Li
, Stephen L. Buchwald

Massachusetts Institute of Technology

科研成果: 期刊稿件 › 文章 › 同行评审

85 引用（Scopus）

摘要

Facilitating chemistry: Key to the success of Pd-catalyzed α-arylation of oxindoles in continuous flow involved a biphasic system, a precatalyst, and a packed-bed microreactor. Furthermore, this reaction was integrated into a two-step continuous-flow sequence for rapid, modular, and efficient syntheses of 3,3-disubstituted oxindoles.

源语言	英语
页（从-至）	6396-6400
页数	5
期刊	Angewandte Chemie - International Edition
卷	50
期	28
DOI	https://doi.org/10.1002/anie.201102401
出版状态	已出版 - 4 7月 2011
已对外发布	是

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KW - biphasic catalysis

KW - continuous flow

KW - multistep reactions

KW - oxindole

KW - α-arylation

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Continuous-flow synthesis of 3,3-disubstituted oxindoles by a palladium-catalyzed α-arylation/alkylation sequence

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