Clinical implications of the platelet test results about unstable angina patients with different conditions of blood glucose

Objective: To study the platelet changes in patients with unstable angina with different blood glucose, and their related biochemical index changes, and their relationship with global registry of acute coronary events (GRACE) score. Methods: For this clinical study, we enrolled 82 patients diagnosed with unstable angina, 47 of whom were male and 35 were female. Upon admission, their random blood glucose was tested. According to different blood glucose values, they were divided into normal blood glucose group (<6.1 mmol/L) and high blood glucose (≥6.1 mmol/L) group. The following clinical data were compared between the two groups: age, hypertension, diabetes, smoking history, and BMI. We detected EF (%), HBA1C, glucose, LDL-C, HDL-C, TG, LPA, CREA, UA, hsCRP, BNP, CKMB, CTNI, D-Dimer, and GRACE risk scores. We compared the platelet test results: PLT, P-LCR, PDW, and MPV. We also detected the relationship of MPV with hsCRP, D-Dimers and GRACE risk scores. Results: MPV, hsCRP, and GRACE risk score differed significantly between normal blood glucose group and high blood glucose group (P<0.05). In the latter group, MPV had significant correlation with hsCRP, D-Dimers and GRACE risk score (r=0.28, r=0.41, r=0.56, P<0.05). Conclusion: Hyperglycemia in patients with unstable angina causes the increase of MPV, change of the inflammatory marker hsCRP, and increase of clinical GRACE risk score. Abnormal MPV may predict the increased risk of unstable angina in patients with hyperglycemia upon hospitalization.