Chemical constituents of Heracleum dissectum and their cytotoxic activity

Yang Gao; Ying Liu; Zhi Gang Wang; Hai Long Zhang

doi:10.1016/j.phytol.2014.10.008

Chemical constituents of Heracleum dissectum and their cytotoxic activity

Yang Gao
, Ying Liu
, Zhi Gang Wang
, Hai Long Zhang

医学部

Chinese Academy of Medical Sciences
Heilongjiang University of Traditional Chinese Medicine
Xi'an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

26 引用（Scopus）

摘要

A new phenylpropanoid, 3-O-(6-O-β-d-xylopyranosyloxy-β-d-glucopyranosyl)-4-hydroxy-1-allylbenzene (1) and a new neolignan glycoside, (7S, 8R)-dehydrodiconiferyl alcohol 4-O-β-d-glucopyranoside-9′-n-butanol ether (2), together with 2 known neolignans (3-4) and 5 known coumarins (5-9) were isolated from the roots of Heracleum dissectum Ledeb. Their structures were elucidated by means of various spectroscopic analyses. Five of the isolated compounds were tested against Hela, HCT-8, and HepG2 cancer cell lines and showed moderate cytotoxic activities with IC₅₀ values between 5.8 and 18.6 μM.

源语言	英语
页（从-至）	276-280
页数	5
期刊	Phytochemistry Letters
卷	10
DOI	https://doi.org/10.1016/j.phytol.2014.10.008
出版状态	已出版 - 12月 2014

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

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10.1016/j.phytol.2014.10.008

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引用此

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title = "Chemical constituents of Heracleum dissectum and their cytotoxic activity",

abstract = "A new phenylpropanoid, 3-O-(6-O-β-d-xylopyranosyloxy-β-d-glucopyranosyl)-4-hydroxy-1-allylbenzene (1) and a new neolignan glycoside, (7S, 8R)-dehydrodiconiferyl alcohol 4-O-β-d-glucopyranoside-9′-n-butanol ether (2), together with 2 known neolignans (3-4) and 5 known coumarins (5-9) were isolated from the roots of Heracleum dissectum Ledeb. Their structures were elucidated by means of various spectroscopic analyses. Five of the isolated compounds were tested against Hela, HCT-8, and HepG2 cancer cell lines and showed moderate cytotoxic activities with IC50 values between 5.8 and 18.6 μM.",

keywords = "Coumarin, Heracleum dissectum, Neolignan glycosides, Phenylpropanoid",

author = "Yang Gao and Ying Liu and Wang, \{Zhi Gang\} and Zhang, \{Hai Long\}",

year = "2014",

month = dec,

doi = "10.1016/j.phytol.2014.10.008",

language = "英语",

volume = "10",

pages = "276--280",

journal = "Phytochemistry Letters",

issn = "1874-3900",

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TY - JOUR

T1 - Chemical constituents of Heracleum dissectum and their cytotoxic activity

AU - Gao, Yang

AU - Liu, Ying

AU - Wang, Zhi Gang

AU - Zhang, Hai Long

PY - 2014/12

Y1 - 2014/12

N2 - A new phenylpropanoid, 3-O-(6-O-β-d-xylopyranosyloxy-β-d-glucopyranosyl)-4-hydroxy-1-allylbenzene (1) and a new neolignan glycoside, (7S, 8R)-dehydrodiconiferyl alcohol 4-O-β-d-glucopyranoside-9′-n-butanol ether (2), together with 2 known neolignans (3-4) and 5 known coumarins (5-9) were isolated from the roots of Heracleum dissectum Ledeb. Their structures were elucidated by means of various spectroscopic analyses. Five of the isolated compounds were tested against Hela, HCT-8, and HepG2 cancer cell lines and showed moderate cytotoxic activities with IC50 values between 5.8 and 18.6 μM.

AB - A new phenylpropanoid, 3-O-(6-O-β-d-xylopyranosyloxy-β-d-glucopyranosyl)-4-hydroxy-1-allylbenzene (1) and a new neolignan glycoside, (7S, 8R)-dehydrodiconiferyl alcohol 4-O-β-d-glucopyranoside-9′-n-butanol ether (2), together with 2 known neolignans (3-4) and 5 known coumarins (5-9) were isolated from the roots of Heracleum dissectum Ledeb. Their structures were elucidated by means of various spectroscopic analyses. Five of the isolated compounds were tested against Hela, HCT-8, and HepG2 cancer cell lines and showed moderate cytotoxic activities with IC50 values between 5.8 and 18.6 μM.

KW - Coumarin

KW - Heracleum dissectum

KW - Neolignan glycosides

KW - Phenylpropanoid

UR - https://www.scopus.com/pages/publications/84908402981

U2 - 10.1016/j.phytol.2014.10.008

DO - 10.1016/j.phytol.2014.10.008

M3 - 文章

AN - SCOPUS:84908402981

SN - 1874-3900

VL - 10

SP - 276

EP - 280

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Chemical constituents of Heracleum dissectum and their cytotoxic activity

摘要

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