TY - JOUR
T1 - Chemical and biological characterization of air particulate matter 2.5, collected from five cities in China
AU - Leung, P. Y.
AU - Wan, H. T.
AU - Billah, M. B.
AU - Cao, J. J.
AU - Ho, K. F.
AU - Wong, Chris K.C.
PY - 2014/11
Y1 - 2014/11
N2 - Fifteen polycyclic aromatic hydrocarbons (PAHs) in PM2.5 samples collected in five different cities (Hong Kong (HK), Guangzhou (GZ), Xiamen (XM), Xi'an (XA) and Beijing (BJ)) in China in the winter 2012-12 were analyzed by gas chromatography-mass spectrometry. The biological effects of organic extracts were assayed using the human bronchial epithelial cells BEAS-2B. All sixteen priority PAHs can be found in the PM2.5 samples of XA and BJ, but not in HK, GZ and XM, demonstrating the differential spatial source and distribution of PAHs. Our results showed that the total PAHs ranged from 3.35 to 80.45 ng/m3 air, leading by BJ, followed by XA, XM, GZ and HK. In the cell culture study, transcript levels of pro-inflammatory cytokine interleukin-6 (IL-6), CYP1A1 and CYP1B1 were found to be induced in the treatment. The cells exposed to extracts from XA and BJ demonstrated significant migratory activities, indicating a sign of increase of tumorigenicity.
AB - Fifteen polycyclic aromatic hydrocarbons (PAHs) in PM2.5 samples collected in five different cities (Hong Kong (HK), Guangzhou (GZ), Xiamen (XM), Xi'an (XA) and Beijing (BJ)) in China in the winter 2012-12 were analyzed by gas chromatography-mass spectrometry. The biological effects of organic extracts were assayed using the human bronchial epithelial cells BEAS-2B. All sixteen priority PAHs can be found in the PM2.5 samples of XA and BJ, but not in HK, GZ and XM, demonstrating the differential spatial source and distribution of PAHs. Our results showed that the total PAHs ranged from 3.35 to 80.45 ng/m3 air, leading by BJ, followed by XA, XM, GZ and HK. In the cell culture study, transcript levels of pro-inflammatory cytokine interleukin-6 (IL-6), CYP1A1 and CYP1B1 were found to be induced in the treatment. The cells exposed to extracts from XA and BJ demonstrated significant migratory activities, indicating a sign of increase of tumorigenicity.
KW - Polycyclic aromatic hydrocarbons
KW - TEF
KW - Tumorigenicity
UR - https://www.scopus.com/pages/publications/84906509320
U2 - 10.1016/j.envpol.2014.07.032
DO - 10.1016/j.envpol.2014.07.032
M3 - 文章
C2 - 25150452
AN - SCOPUS:84906509320
SN - 0269-7491
VL - 194
SP - 188
EP - 195
JO - Environmental Pollution
JF - Environmental Pollution
ER -