TY - JOUR
T1 - Cerebral Hemodynamic Correlates of Transcutaneous Auricular Vagal Nerve Stimulation in Consciousness Restoration
T2 - An Open-Label Pilot Study
AU - Yu, Yutian
AU - Yang, Yi
AU - Gan, Shuoqiu
AU - Guo, Shengnan
AU - Fang, Jiliang
AU - Wang, Shouyan
AU - Tang, Chunzhi
AU - Bai, Lijun
AU - He, Jianghong
AU - Rong, Peijing
N1 - Publisher Copyright:
© Copyright © 2021 Yu, Yang, Gan, Guo, Fang, Wang, Tang, Bai, He and Rong.
PY - 2021/7/15
Y1 - 2021/7/15
N2 - This study aimed to preliminarily illustrate the cerebral hemodynamic correlates of transcutaneous auricular vagal nerve stimulation (taVNS) in consciousness restoration. Arterial spin labeling (ASL) was adopted with functional magnetic resonance imaging (fMRI) to measure cerebral blood flow (CBF) changes before and after taVNS in 10 qualified patients with disorders of consciousness (DOC). Before taVNS, five patients responded to auditory stimuli (RtAS), and five did not respond to auditory stimuli (nRtAS). The RtAS DOC patients obtained favorable prognoses after the 4-week taVNS treatment, whereas the nRtAS ones did not. Simultaneously, taVNS increased CBF of multiple brain regions in the RtAS DOC patients, but hardly in the nRtAS ones. In conclusion, the preserved auditory function might be the prior key factor of the taVNS responders in DOC patients, and taVNS might alleviate RtAS DOC by activating the salience network, the limbic system, and the interoceptive system.
AB - This study aimed to preliminarily illustrate the cerebral hemodynamic correlates of transcutaneous auricular vagal nerve stimulation (taVNS) in consciousness restoration. Arterial spin labeling (ASL) was adopted with functional magnetic resonance imaging (fMRI) to measure cerebral blood flow (CBF) changes before and after taVNS in 10 qualified patients with disorders of consciousness (DOC). Before taVNS, five patients responded to auditory stimuli (RtAS), and five did not respond to auditory stimuli (nRtAS). The RtAS DOC patients obtained favorable prognoses after the 4-week taVNS treatment, whereas the nRtAS ones did not. Simultaneously, taVNS increased CBF of multiple brain regions in the RtAS DOC patients, but hardly in the nRtAS ones. In conclusion, the preserved auditory function might be the prior key factor of the taVNS responders in DOC patients, and taVNS might alleviate RtAS DOC by activating the salience network, the limbic system, and the interoceptive system.
KW - arterial spin labeling (ASL)
KW - cerebral blood flow (CBF)
KW - disorders of consciousness (DOC)
KW - functional magnetic resonance imaging (fMRI)
KW - non-responded to auditory stimuli (nRtAS)
KW - responded to auditory stimuli (RtAS)
KW - transcutaneous auricular vagal nerve stimulation (taVNS)
UR - https://www.scopus.com/pages/publications/85111579089
U2 - 10.3389/fneur.2021.684791
DO - 10.3389/fneur.2021.684791
M3 - 文章
AN - SCOPUS:85111579089
SN - 1664-2295
VL - 12
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 684791
ER -