Carbonylation of C(sp³)—X Bonds Utilizing CO

The transition metal catalyzed Csp³ carbonylation is becoming a more and more important tool to synthesize kinds of aliphatic carbonyl-containing derivatives. The CO molecule could be introduced into the organic molecules as a vital functional group. In this chapter, we review the transition-metal-catalyzed carbonylation of Csp³ compounds. Various β, γ-unsaturated carbonyl compounds, aliphatic carboxylic acid, and their derivatives could be achieved from allylic compounds, benzyl compounds, aliphatic compounds, etc. Finally, we summarize the current progress in the Csp³ carbonylation and look forward its development.