TY - JOUR
T1 - Capillary electrophoresis coupled with electrochemiluminescence for determination of cloperastine hydrochloride
AU - Xiong, Fengmei
AU - Tang, Xiaoshuang
AU - Tang, Yuhai
AU - Tuerho, Muhetaer
AU - Sun, Sijuan
AU - Zhang, Guangbin
AU - Li, Haiyan
PY - 2008/11
Y1 - 2008/11
N2 - Objective: To investigate the electrochemiluminescence (ECL) behavior of cloperastine hydrochloride. Methods: ECL intensity of tris (2,2′-bipyridyl) rutheniumo(II) was enhanced, the method for the determination of cloperastine hydrochloride was established using capillary electrophoresis (CE) coupled with electrochemilumolinescence (ECL) detection. Results: Under the optimum conditions, ECL intensity varied linearly with cloperastine hydrochloride concentration from 7.0 × 10-6g/mL to 1.0 × 10-4g/mL. The detection limit (S/N=3) was 8.05 × 10-7 g/mL. The relative standard deviation of the ECL intensity and the migration time for 11 consecutive iajections of 1.0 × 10-5 g/mL cloperastine hydrochloride was 2.9% and 1.5%, respectively. This method was successfully applied to cloperastine hydrochloride tablet determination. Conclusion: The method has been established, validated and applied for determination of cloperastine hydrochloride.
AB - Objective: To investigate the electrochemiluminescence (ECL) behavior of cloperastine hydrochloride. Methods: ECL intensity of tris (2,2′-bipyridyl) rutheniumo(II) was enhanced, the method for the determination of cloperastine hydrochloride was established using capillary electrophoresis (CE) coupled with electrochemilumolinescence (ECL) detection. Results: Under the optimum conditions, ECL intensity varied linearly with cloperastine hydrochloride concentration from 7.0 × 10-6g/mL to 1.0 × 10-4g/mL. The detection limit (S/N=3) was 8.05 × 10-7 g/mL. The relative standard deviation of the ECL intensity and the migration time for 11 consecutive iajections of 1.0 × 10-5 g/mL cloperastine hydrochloride was 2.9% and 1.5%, respectively. This method was successfully applied to cloperastine hydrochloride tablet determination. Conclusion: The method has been established, validated and applied for determination of cloperastine hydrochloride.
KW - Capillary electrochemiluminescence
KW - Cloperastine hydrochloride
KW - Tris-(2,2′-bipyridyl) ruthenium (II)
UR - https://www.scopus.com/pages/publications/57849110547
M3 - 文章
AN - SCOPUS:57849110547
SN - 1671-8267
VL - 20
SP - 274
EP - 277
JO - Academic Journal of Xi'an Jiaotong University
JF - Academic Journal of Xi'an Jiaotong University
IS - 4
ER -