TY - JOUR
T1 - c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy
AU - Gao, Lan
AU - Shi, Qindong
AU - Sun, Bin
AU - Zhang, Xiaoyu
AU - Zheng, Peiying
AU - Zhou, Linjing
AU - Tian, Gang
AU - Li, Hao
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/8
Y1 - 2025/8
N2 - This study investigates the role of c-FLIP in sepsis-induced myocardial dysfunction (SIMD), focusing on cardiac microcirculation and mitochondrial autophagy. Using SIMD rat and LPS-induced cardiac microvascular endothelial cell injury models, we found that c-FLIP deficiency disrupts mitochondrial homeostasis, exacerbating microcirculatory damage. c-FLIP differentially regulates mitochondrial autophagy via FUNDC1. Overexpression of c-FLIP balances autophagy, protects mitochondria, reduces inflammation, and ameliorates SIMD, highlighting its potential as a therapeutic target.
AB - This study investigates the role of c-FLIP in sepsis-induced myocardial dysfunction (SIMD), focusing on cardiac microcirculation and mitochondrial autophagy. Using SIMD rat and LPS-induced cardiac microvascular endothelial cell injury models, we found that c-FLIP deficiency disrupts mitochondrial homeostasis, exacerbating microcirculatory damage. c-FLIP differentially regulates mitochondrial autophagy via FUNDC1. Overexpression of c-FLIP balances autophagy, protects mitochondria, reduces inflammation, and ameliorates SIMD, highlighting its potential as a therapeutic target.
KW - FUNDC1
KW - JNK pathway
KW - c-FLIP
KW - cardiac microcirculation
KW - mitochondrial autophagy
KW - sepsis-induced myocardial dysfunction (SIMD)
UR - https://www.scopus.com/pages/publications/105006940478
U2 - 10.1016/j.jacbts.2025.02.016
DO - 10.1016/j.jacbts.2025.02.016
M3 - 文章
AN - SCOPUS:105006940478
SN - 2452-302X
VL - 10
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 8
M1 - 101257
ER -