Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

Annadurai Anandhan; Matthew Dodson; Cody J. Schmidlin; Pengfei Liu; Donna D. Zhang

doi:10.1016/j.chembiol.2020.03.011

Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

Annadurai Anandhan
, Matthew Dodson
, Cody J. Schmidlin
, Pengfei Liu
, Donna D. Zhang

University of Arizona

科研成果: 期刊稿件 › 文献综述 › 同行评审

404 引用（Scopus）

摘要

In this review, Anandhan and Dodson et al. summarize key components of the ferroptosis cascade, including recent experimental evidence indicating a role for this novel mode of cell death in disease. The concept of targeting upstream mediators of ferroptosis, including the NRF2 pathway, to treat disease is also discussed.

源语言	英语
页（从-至）	436-447
页数	12
期刊	Cell Chemical Biology
卷	27
期	4
DOI	https://doi.org/10.1016/j.chembiol.2020.03.011
出版状态	已出版 - 16 4月 2020
已对外发布	是

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10.1016/j.chembiol.2020.03.011

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title = "Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis",

abstract = "In this review, Anandhan and Dodson et al. summarize key components of the ferroptosis cascade, including recent experimental evidence indicating a role for this novel mode of cell death in disease. The concept of targeting upstream mediators of ferroptosis, including the NRF2 pathway, to treat disease is also discussed.",

keywords = "NRF2, cancer, cardiovascular disease, cell death, diabetes, ferritinophagy, ferroptosis, iron, lipid peroxidation, neurodegeneration",

author = "Annadurai Anandhan and Matthew Dodson and Schmidlin, \{Cody J.\} and Pengfei Liu and Zhang, \{Donna D.\}",

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day = "16",

doi = "10.1016/j.chembiol.2020.03.011",

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T2 - The Critical Role of NRF2 in Mediating Ferroptosis

AU - Anandhan, Annadurai

AU - Dodson, Matthew

AU - Schmidlin, Cody J.

AU - Liu, Pengfei

AU - Zhang, Donna D.

PY - 2020/4/16

Y1 - 2020/4/16

N2 - In this review, Anandhan and Dodson et al. summarize key components of the ferroptosis cascade, including recent experimental evidence indicating a role for this novel mode of cell death in disease. The concept of targeting upstream mediators of ferroptosis, including the NRF2 pathway, to treat disease is also discussed.

AB - In this review, Anandhan and Dodson et al. summarize key components of the ferroptosis cascade, including recent experimental evidence indicating a role for this novel mode of cell death in disease. The concept of targeting upstream mediators of ferroptosis, including the NRF2 pathway, to treat disease is also discussed.

KW - NRF2

KW - cancer

KW - cardiovascular disease

KW - cell death

KW - diabetes

KW - ferritinophagy

KW - ferroptosis

KW - iron

KW - lipid peroxidation

KW - neurodegeneration

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DO - 10.1016/j.chembiol.2020.03.011

M3 - 文献综述

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AN - SCOPUS:85082958645

SN - 2451-9456

VL - 27

SP - 436

EP - 447

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 4

ER -

Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

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