TY - JOUR
T1 - BMP-SHH Signaling Network Controls Epithelial Stem Cell Fate via Regulation of Its Niche in the Developing Tooth
AU - Li, Jingyuan
AU - Feng, Jifan
AU - Liu, Yang
AU - Ho, Thach Vu
AU - Grimes, Weston
AU - Ho, Hoang Anh
AU - Park, Shery
AU - Wang, Songlin
AU - Chai, Yang
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/4/20
Y1 - 2015/4/20
N2 - During embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal organs, such as teeth, hair follicles, mammary glands, and salivary glands. Interestingly, these ectodermal organs differ in their tissue homeostasis, which leads to differential abilities for continuous growth postnatally. Mouse molars lose the ability to grow continuously, whereas incisors retain this ability. In this study, we found that a BMP-Smad4-SHH-Gli1 signaling network may provide a niche supporting transient Sox2+ dental epithelial stem cells in mouse molars. This mechanism also plays a role in continuously growing mouse incisors. The differential fate of epithelial stem cells in mouse molars and incisors is controlled by this BMP/SHH signaling network, which partially accounts for the different postnatal growth potential of molars and incisors. Collectively, our study highlights the importance of crosstalk between two signaling pathways, BMP and SHH, inregulating the fate of epithelial stem cells during organogenesis.
AB - During embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal organs, such as teeth, hair follicles, mammary glands, and salivary glands. Interestingly, these ectodermal organs differ in their tissue homeostasis, which leads to differential abilities for continuous growth postnatally. Mouse molars lose the ability to grow continuously, whereas incisors retain this ability. In this study, we found that a BMP-Smad4-SHH-Gli1 signaling network may provide a niche supporting transient Sox2+ dental epithelial stem cells in mouse molars. This mechanism also plays a role in continuously growing mouse incisors. The differential fate of epithelial stem cells in mouse molars and incisors is controlled by this BMP/SHH signaling network, which partially accounts for the different postnatal growth potential of molars and incisors. Collectively, our study highlights the importance of crosstalk between two signaling pathways, BMP and SHH, inregulating the fate of epithelial stem cells during organogenesis.
UR - https://www.scopus.com/pages/publications/84928092998
U2 - 10.1016/j.devcel.2015.02.021
DO - 10.1016/j.devcel.2015.02.021
M3 - 文章
C2 - 25865348
AN - SCOPUS:84928092998
SN - 1534-5807
VL - 33
SP - 125
EP - 135
JO - Developmental Cell
JF - Developmental Cell
IS - 2
ER -