TY - JOUR
T1 - Bioengineered Violet Phosphorus Hybrid Nanoassembly for Pathogen-Specific Eradication of Multidrug-Resistant Bacteria
AU - Liu, Hening
AU - Zhu, Yuanbo
AU - Li, Zixuan
AU - Shu, Weijie
AU - Yin, Yue
AU - Hou, Yi
AU - Mei, Yijun
AU - Fu, Cong
AU - Gao, Jifan
AU - Zhang, Yi
AU - Wang, Zihan
AU - Wang, Zixuan
AU - Zhang, Jinying
AU - Tang, Lu
AU - Wang, Wei
N1 - Publisher Copyright:
© 2025 Wiley-VCH GmbH.
PY - 2025
Y1 - 2025
N2 - As an emerging 2D material, violet phosphorus nanosheet (VPN) has gained considerable attention since its first coverage in 2019. However, its potential in biomedical applications remains largely unexplored. Herein, a VPN-based hybrid nanoassembly is presented for specific navigation and eradication of methicillin-resistant Staphylococcus aureus (MRSA). Particularly, macrophage membrane preconditioned with MRSA is extracted to construct a bioengineered nanoshell, which is further cloaked onto vancomycin (Van)-loaded, photodynamically active VPN to fabricate Van/VPN@M for combating multidrug-resistant (MDR) bacteria-related local skin infections. Leveraging this bioinspired coating, Van/VPN@M enables precise, infection site-targeted delivery and synergistic antibacterial action. Upon laser irradiation, Van/VPN@M completely eradicates MDR bacteria, relieves local inflammation, and promotes skin repair in murine models of MRSA-infected wound and subcutaneous abscess. Collectively, this versatile antibacterial platform not only expands the biomedical applicability of VPN, but also holds great promise to advance the therapeutic options for MDR bacteria-associated infections.
AB - As an emerging 2D material, violet phosphorus nanosheet (VPN) has gained considerable attention since its first coverage in 2019. However, its potential in biomedical applications remains largely unexplored. Herein, a VPN-based hybrid nanoassembly is presented for specific navigation and eradication of methicillin-resistant Staphylococcus aureus (MRSA). Particularly, macrophage membrane preconditioned with MRSA is extracted to construct a bioengineered nanoshell, which is further cloaked onto vancomycin (Van)-loaded, photodynamically active VPN to fabricate Van/VPN@M for combating multidrug-resistant (MDR) bacteria-related local skin infections. Leveraging this bioinspired coating, Van/VPN@M enables precise, infection site-targeted delivery and synergistic antibacterial action. Upon laser irradiation, Van/VPN@M completely eradicates MDR bacteria, relieves local inflammation, and promotes skin repair in murine models of MRSA-infected wound and subcutaneous abscess. Collectively, this versatile antibacterial platform not only expands the biomedical applicability of VPN, but also holds great promise to advance the therapeutic options for MDR bacteria-associated infections.
KW - bacterial navigation
KW - nanoassembly
KW - photodynamic therapy
KW - skin infections
KW - violet phosphorus nanosheet
UR - https://www.scopus.com/pages/publications/105018184212
U2 - 10.1002/adfm.202518779
DO - 10.1002/adfm.202518779
M3 - 文章
AN - SCOPUS:105018184212
SN - 1616-301X
JO - Advanced Functional Materials
JF - Advanced Functional Materials
ER -