Associations between short-term exposure of ambient particulate matter and hemodialysis patients death: A nationwide, longitudinal case-control study in China

Xiaowei Lou; Ping Zhang; Nan Shi; Zhe Ding; Zhonggao Xu; Bicheng Liu; Wenbo Hu; Tiekun Yan; Jinwen Wang; Ling Liu; Yan Zha; Jianqin Wang; Wei Chen; Chenyun Xu; Jinsheng Xu; Hongli Jiang; Huichao Ma; Weijie Yuan; Caili Wang; Yunhua Liao; Deguang Wang; Li Yao; Menghua Chen; Guisen Li; Yun Li; Pei Wang; Xuemei Li; Chen Lu; Wenzhuang Tang; Jianxin Wan; Rongshan Li; Xiangcheng Xiao; Chun Zhang; Jundong Jiao; Wei Zhang; Jing Yuan; Lan Lan; Jingsong Li; Peng Zhang; Weijun Zheng; Jianghua Chen

doi:10.1016/j.scitotenv.2022.158215

Associations between short-term exposure of ambient particulate matter and hemodialysis patients death: A nationwide, longitudinal case-control study in China

Xiaowei Lou
, Ping Zhang
, Nan Shi
, Zhe Ding
, Zhonggao Xu
, Bicheng Liu
, Wenbo Hu
, Tiekun Yan
, Jinwen Wang
, Ling Liu
, Yan Zha
, Jianqin Wang
, Wei Chen
, Chenyun Xu
, Jinsheng Xu
, Hongli Jiang
, Huichao Ma
, Weijie Yuan
, Caili Wang
, Yunhua Liao

Deguang Wang, Li Yao, Menghua Chen, Guisen Li, Yun Li, Pei Wang, Xuemei Li, Chen Lu, Wenzhuang Tang, Jianxin Wan, Rongshan Li, Xiangcheng Xiao, Chun Zhang, Jundong Jiao, Wei Zhang, Jing Yuan, Lan Lan, Jingsong Li, Peng Zhang, Weijun Zheng, Jianghua Chen

Zhejiang University School of Medicine
National Key Clinical Department of Kidney Diseases
Zhejiang University
Zhejiang dialysis quality control center
Jilin University
Zhongda Hospital Southeast University
Qinghai Provincial Peoples Hospital
Tianjin Medical University
Kunming Medical College
The Second Affiliated Hospital of Chongqing Medical University
Guizhou Provincial People's Hospital
Lanzhou University
First Affiliated Hospital of Sun Yat sen University
Nanchang University
Hebei Medical University
The First Affiliated Hospital of Xi’an Jiaotong University
Second Hospital of Tibet Autonomous Region
Shanghai Jiao Tong University
Baotou Medical College
The First Affiliated Hospital of Guangxi Medical University
Anhui Medical University
First Affiliated Hospital of China Medical University
Ningxia Medical University
Sichuan Provincial People's Hospital
Jiangxi Provincial Peoples Hospital
First Affiliated Hospital of Zhengzhou University
Chinese Academy of Medical Sciences
Peoples Hospital of Xinjiang Uygur Autonomous Region
Hainan Medical University
Fujian Medical University
Shaanxi Provincial People's Hospital
Central South University
Huazhong University of Science and Technology
Harbin Medical University
Research Center for Healthcare Data Science
Zhejiang Chinese Medical University

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5 引用（Scopus）

摘要

Background: Long-term exposure to particulate air pollutants can lead to an increase in mortality of hemodialysis patients, but evidence of mortality risk with short-term exposure to ambient particulate matter is lacking. This study aimed to estimate the association of short-term exposure to ambient particulate matter across a wide range of concentrations with hemodialysis patients mortality. Methods: We performed a time-stratified case-crossover study to estimate the association between short-term exposures to PM_2.5 and PM₁₀ and mortality of hemodialysis patients. The study included 18,114 hemodialysis death case from 279 hospitals in 41 cities since 2013. Daily particulate matter exposures were calculated by the inverse distance–weighted model based on each case's dialysis center address. Conditional logistic regression were implemented to quantify exposure-response associations. The sensitivity analysis mainly explored the lag effect of particulate matter. Results: During the study period, there were 18,114 case days and 61,726 control days. Of all case and control days, average PM_2.5 and PM₁₀ levels were 43.98 μg/m³ and 70.86 μg/m³, respectively. Each short-term increase of 10 μg/m³ in PM_2.5 and PM₁₀ were statistically significantly associated with a relative increase of 1.07 % (95 % confidence interval [CI]: 0.99 % - 1.15 %) and 0.89 % (95 % CI: 0.84 % - 0.94 %) in daily mortality rate of hemodialysis patients, respectively. There was no evidence of a threshold in the exposure-response relationship. The mean of daily exposure on the same day of death and one-day prior (Lag 01 Day) was the most plausible exposure time window. Conclusions: This study confirms that short-term exposure to particulate matter leads to increased mortality in hemodialysis patients. Policy makers and public health practices have a clear and urgent opportunity to pass air quality control policies that care for hemodialysis populations and incorporate air quality into the daily medical management of hemodialysis patients.

源语言	英语
文章编号	158215
期刊	Science of the Total Environment
卷	852
DOI	https://doi.org/10.1016/j.scitotenv.2022.158215
出版状态	已出版 - 15 12月 2022
已对外发布	是

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉
可持续发展目标 11 可持续城市和社区

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10.1016/j.scitotenv.2022.158215

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Lou, X., Zhang, P., Shi, N., Ding, Z., Xu, Z., Liu, B., Hu, W., Yan, T., Wang, J., Liu, L., Zha, Y., Wang, J., Chen, W., Xu, C., Xu, J., Jiang, H., Ma, H., Yuan, W., Wang, C., ... Chen, J. (2022). Associations between short-term exposure of ambient particulate matter and hemodialysis patients death: A nationwide, longitudinal case-control study in China. Science of the Total Environment, 852, 文章 158215. https://doi.org/10.1016/j.scitotenv.2022.158215

@article{382e7efc2691439cba43a77005982f2f,

title = "Associations between short-term exposure of ambient particulate matter and hemodialysis patients death: A nationwide, longitudinal case-control study in China",

abstract = "Background: Long-term exposure to particulate air pollutants can lead to an increase in mortality of hemodialysis patients, but evidence of mortality risk with short-term exposure to ambient particulate matter is lacking. This study aimed to estimate the association of short-term exposure to ambient particulate matter across a wide range of concentrations with hemodialysis patients mortality. Methods: We performed a time-stratified case-crossover study to estimate the association between short-term exposures to PM2.5 and PM10 and mortality of hemodialysis patients. The study included 18,114 hemodialysis death case from 279 hospitals in 41 cities since 2013. Daily particulate matter exposures were calculated by the inverse distance–weighted model based on each case's dialysis center address. Conditional logistic regression were implemented to quantify exposure-response associations. The sensitivity analysis mainly explored the lag effect of particulate matter. Results: During the study period, there were 18,114 case days and 61,726 control days. Of all case and control days, average PM2.5 and PM10 levels were 43.98 μg/m3 and 70.86 μg/m3, respectively. Each short-term increase of 10 μg/m3 in PM2.5 and PM10 were statistically significantly associated with a relative increase of 1.07 \% (95 \% confidence interval [CI]: 0.99 \% - 1.15 \%) and 0.89 \% (95 \% CI: 0.84 \% - 0.94 \%) in daily mortality rate of hemodialysis patients, respectively. There was no evidence of a threshold in the exposure-response relationship. The mean of daily exposure on the same day of death and one-day prior (Lag 01 Day) was the most plausible exposure time window. Conclusions: This study confirms that short-term exposure to particulate matter leads to increased mortality in hemodialysis patients. Policy makers and public health practices have a clear and urgent opportunity to pass air quality control policies that care for hemodialysis populations and incorporate air quality into the daily medical management of hemodialysis patients.",

keywords = "Ambient PM, Hemodialysis, Mortality, Short-term exposure",

author = "Xiaowei Lou and Ping Zhang and Nan Shi and Zhe Ding and Zhonggao Xu and Bicheng Liu and Wenbo Hu and Tiekun Yan and Jinwen Wang and Ling Liu and Yan Zha and Jianqin Wang and Wei Chen and Chenyun Xu and Jinsheng Xu and Hongli Jiang and Huichao Ma and Weijie Yuan and Caili Wang and Yunhua Liao and Deguang Wang and Li Yao and Menghua Chen and Guisen Li and Yun Li and Pei Wang and Xuemei Li and Chen Lu and Wenzhuang Tang and Jianxin Wan and Rongshan Li and Xiangcheng Xiao and Chun Zhang and Jundong Jiao and Wei Zhang and Jing Yuan and Lan Lan and Jingsong Li and Peng Zhang and Weijun Zheng and Jianghua Chen",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = dec,

day = "15",

doi = "10.1016/j.scitotenv.2022.158215",

language = "英语",

volume = "852",

journal = "Science of the Total Environment",

issn = "0048-9697",

publisher = "Elsevier B.V.",

}

Lou, X, Zhang, P, Shi, N, Ding, Z, Xu, Z, Liu, B, Hu, W, Yan, T, Wang, J, Liu, L, Zha, Y, Wang, J, Chen, W, Xu, C, Xu, J, Jiang, H, Ma, H, Yuan, W, Wang, C, Liao, Y, Wang, D, Yao, L, Chen, M, Li, G, Li, Y, Wang, P, Li, X, Lu, C, Tang, W, Wan, J, Li, R, Xiao, X, Zhang, C, Jiao, J, Zhang, W, Yuan, J, Lan, L, Li, J, Zhang, P, Zheng, W & Chen, J 2022, 'Associations between short-term exposure of ambient particulate matter and hemodialysis patients death: A nationwide, longitudinal case-control study in China', Science of the Total Environment, 卷 852, 158215. https://doi.org/10.1016/j.scitotenv.2022.158215

TY - JOUR

T1 - Associations between short-term exposure of ambient particulate matter and hemodialysis patients death

T2 - A nationwide, longitudinal case-control study in China

AU - Lou, Xiaowei

AU - Zhang, Ping

AU - Shi, Nan

AU - Ding, Zhe

AU - Xu, Zhonggao

AU - Liu, Bicheng

AU - Hu, Wenbo

AU - Yan, Tiekun

AU - Wang, Jinwen

AU - Liu, Ling

AU - Zha, Yan

AU - Wang, Jianqin

AU - Chen, Wei

AU - Xu, Chenyun

AU - Xu, Jinsheng

AU - Jiang, Hongli

AU - Ma, Huichao

AU - Yuan, Weijie

AU - Wang, Caili

AU - Liao, Yunhua

AU - Wang, Deguang

AU - Yao, Li

AU - Chen, Menghua

AU - Li, Guisen

AU - Li, Yun

AU - Wang, Pei

AU - Li, Xuemei

AU - Lu, Chen

AU - Tang, Wenzhuang

AU - Wan, Jianxin

AU - Li, Rongshan

AU - Xiao, Xiangcheng

AU - Zhang, Chun

AU - Jiao, Jundong

AU - Zhang, Wei

AU - Yuan, Jing

AU - Lan, Lan

AU - Li, Jingsong

AU - Zhang, Peng

AU - Zheng, Weijun

AU - Chen, Jianghua

PY - 2022/12/15

Y1 - 2022/12/15

N2 - Background: Long-term exposure to particulate air pollutants can lead to an increase in mortality of hemodialysis patients, but evidence of mortality risk with short-term exposure to ambient particulate matter is lacking. This study aimed to estimate the association of short-term exposure to ambient particulate matter across a wide range of concentrations with hemodialysis patients mortality. Methods: We performed a time-stratified case-crossover study to estimate the association between short-term exposures to PM2.5 and PM10 and mortality of hemodialysis patients. The study included 18,114 hemodialysis death case from 279 hospitals in 41 cities since 2013. Daily particulate matter exposures were calculated by the inverse distance–weighted model based on each case's dialysis center address. Conditional logistic regression were implemented to quantify exposure-response associations. The sensitivity analysis mainly explored the lag effect of particulate matter. Results: During the study period, there were 18,114 case days and 61,726 control days. Of all case and control days, average PM2.5 and PM10 levels were 43.98 μg/m3 and 70.86 μg/m3, respectively. Each short-term increase of 10 μg/m3 in PM2.5 and PM10 were statistically significantly associated with a relative increase of 1.07 % (95 % confidence interval [CI]: 0.99 % - 1.15 %) and 0.89 % (95 % CI: 0.84 % - 0.94 %) in daily mortality rate of hemodialysis patients, respectively. There was no evidence of a threshold in the exposure-response relationship. The mean of daily exposure on the same day of death and one-day prior (Lag 01 Day) was the most plausible exposure time window. Conclusions: This study confirms that short-term exposure to particulate matter leads to increased mortality in hemodialysis patients. Policy makers and public health practices have a clear and urgent opportunity to pass air quality control policies that care for hemodialysis populations and incorporate air quality into the daily medical management of hemodialysis patients.

AB - Background: Long-term exposure to particulate air pollutants can lead to an increase in mortality of hemodialysis patients, but evidence of mortality risk with short-term exposure to ambient particulate matter is lacking. This study aimed to estimate the association of short-term exposure to ambient particulate matter across a wide range of concentrations with hemodialysis patients mortality. Methods: We performed a time-stratified case-crossover study to estimate the association between short-term exposures to PM2.5 and PM10 and mortality of hemodialysis patients. The study included 18,114 hemodialysis death case from 279 hospitals in 41 cities since 2013. Daily particulate matter exposures were calculated by the inverse distance–weighted model based on each case's dialysis center address. Conditional logistic regression were implemented to quantify exposure-response associations. The sensitivity analysis mainly explored the lag effect of particulate matter. Results: During the study period, there were 18,114 case days and 61,726 control days. Of all case and control days, average PM2.5 and PM10 levels were 43.98 μg/m3 and 70.86 μg/m3, respectively. Each short-term increase of 10 μg/m3 in PM2.5 and PM10 were statistically significantly associated with a relative increase of 1.07 % (95 % confidence interval [CI]: 0.99 % - 1.15 %) and 0.89 % (95 % CI: 0.84 % - 0.94 %) in daily mortality rate of hemodialysis patients, respectively. There was no evidence of a threshold in the exposure-response relationship. The mean of daily exposure on the same day of death and one-day prior (Lag 01 Day) was the most plausible exposure time window. Conclusions: This study confirms that short-term exposure to particulate matter leads to increased mortality in hemodialysis patients. Policy makers and public health practices have a clear and urgent opportunity to pass air quality control policies that care for hemodialysis populations and incorporate air quality into the daily medical management of hemodialysis patients.

KW - Ambient PM

KW - Hemodialysis

KW - Mortality

KW - Short-term exposure

UR - https://www.scopus.com/pages/publications/85137162346

U2 - 10.1016/j.scitotenv.2022.158215

DO - 10.1016/j.scitotenv.2022.158215

M3 - 文章

C2 - 36028020

AN - SCOPUS:85137162346

SN - 0048-9697

VL - 852

JO - Science of the Total Environment

JF - Science of the Total Environment

M1 - 158215

ER -

Associations between short-term exposure of ambient particulate matter and hemodialysis patients death: A nationwide, longitudinal case-control study in China

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