Associations between C1772T polymorphism in hypoxia-inducible factor-1α gene and breast cancer: A meta-analysis

Hong Tao Ren; Xi Jing Wang; Hua Feng Kang; Shuai Lin; Meng Wang; Zhi Jun Dai

doi:10.12659/MSM.892374

Associations between C1772T polymorphism in hypoxia-inducible factor-1α gene and breast cancer: A meta-analysis

Hong Tao Ren
, Xi Jing Wang
, Hua Feng Kang
, Shuai Lin
, Meng Wang
, Zhi Jun Dai

The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

12 引用（Scopus）

摘要

Background: A meta-analysis was performed to estimate the association between HIF-1a polymorphism (C1772T) and breast cancer risk.

Material/Methods: The relevant published literature was retrieved from PubMed, Web of Knowledge, and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations.

Results: Six case-control studies, including 2043 cases and 2146 controls were identified. Meta-analysis showed that there was no marked association between C1772T polymorphism and breast cancer risk in the overall population in the dominant model. The subgroup analysis showed an increased breast cancer risk in Asians based on homozygote comparison and the recessive model. There were no associations between C1772T polymorphism with clinicopathological parameters and habits.

Conclusions: The present meta-analysis suggests that HIF-1α C1772T polymorphism is a risk factor for susceptibility to breast cancer in Asians.

源语言	英语
页（从-至）	2578-2583
页数	6
期刊	Medical Science Monitor
卷	20
DOI	https://doi.org/10.12659/MSM.892374
出版状态	已出版 - 8 12月 2014
已对外发布	是

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可持续发展目标 3 良好健康与福祉

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10.12659/MSM.892374

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@article{55c62d27afb74d9fbe8d66d27bdb11e5,

title = "Associations between C1772T polymorphism in hypoxia-inducible factor-1α gene and breast cancer: A meta-analysis",

abstract = "Background: A meta-analysis was performed to estimate the association between HIF-1a polymorphism (C1772T) and breast cancer risk.Material/Methods: The relevant published literature was retrieved from PubMed, Web of Knowledge, and Embase. Odds ratios (ORs) and 95\% confidence intervals (CIs) were calculated to estimate the strength of the associations.Results: Six case-control studies, including 2043 cases and 2146 controls were identified. Meta-analysis showed that there was no marked association between C1772T polymorphism and breast cancer risk in the overall population in the dominant model. The subgroup analysis showed an increased breast cancer risk in Asians based on homozygote comparison and the recessive model. There were no associations between C1772T polymorphism with clinicopathological parameters and habits.Conclusions: The present meta-analysis suggests that HIF-1α C1772T polymorphism is a risk factor for susceptibility to breast cancer in Asians.",

keywords = "Alpha subunit, Breast disease, Genetic, Hypoxia-inducible factor 1, Meta-Analysis, Polymorphism",

author = "Ren, \{Hong Tao\} and Wang, \{Xi Jing\} and Kang, \{Hua Feng\} and Shuai Lin and Meng Wang and Dai, \{Zhi Jun\}",

note = "Publisher Copyright: {\textcopyright} Med Sci Monit, 2014.",

year = "2014",

month = dec,

day = "8",

doi = "10.12659/MSM.892374",

language = "英语",

volume = "20",

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TY - JOUR

T1 - Associations between C1772T polymorphism in hypoxia-inducible factor-1α gene and breast cancer

T2 - A meta-analysis

AU - Ren, Hong Tao

AU - Wang, Xi Jing

AU - Kang, Hua Feng

AU - Lin, Shuai

AU - Wang, Meng

AU - Dai, Zhi Jun

N1 - Publisher Copyright: © Med Sci Monit, 2014.

PY - 2014/12/8

Y1 - 2014/12/8

N2 - Background: A meta-analysis was performed to estimate the association between HIF-1a polymorphism (C1772T) and breast cancer risk.Material/Methods: The relevant published literature was retrieved from PubMed, Web of Knowledge, and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations.Results: Six case-control studies, including 2043 cases and 2146 controls were identified. Meta-analysis showed that there was no marked association between C1772T polymorphism and breast cancer risk in the overall population in the dominant model. The subgroup analysis showed an increased breast cancer risk in Asians based on homozygote comparison and the recessive model. There were no associations between C1772T polymorphism with clinicopathological parameters and habits.Conclusions: The present meta-analysis suggests that HIF-1α C1772T polymorphism is a risk factor for susceptibility to breast cancer in Asians.

AB - Background: A meta-analysis was performed to estimate the association between HIF-1a polymorphism (C1772T) and breast cancer risk.Material/Methods: The relevant published literature was retrieved from PubMed, Web of Knowledge, and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations.Results: Six case-control studies, including 2043 cases and 2146 controls were identified. Meta-analysis showed that there was no marked association between C1772T polymorphism and breast cancer risk in the overall population in the dominant model. The subgroup analysis showed an increased breast cancer risk in Asians based on homozygote comparison and the recessive model. There were no associations between C1772T polymorphism with clinicopathological parameters and habits.Conclusions: The present meta-analysis suggests that HIF-1α C1772T polymorphism is a risk factor for susceptibility to breast cancer in Asians.

KW - Alpha subunit

KW - Breast disease

KW - Genetic

KW - Hypoxia-inducible factor 1

KW - Meta-Analysis

KW - Polymorphism

UR - https://www.scopus.com/pages/publications/84924758537

U2 - 10.12659/MSM.892374

DO - 10.12659/MSM.892374

M3 - 文章

C2 - 25484025

AN - SCOPUS:84924758537

SN - 1234-1010

VL - 20

SP - 2578

EP - 2583

JO - Medical Science Monitor

JF - Medical Science Monitor

ER -

Associations between C1772T polymorphism in hypoxia-inducible factor-1α gene and breast cancer: A meta-analysis

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