Application of pharmacogenomics in pharmacokinetic study

Pharmacogenomics is a burgeoning discipline and is being developed rapidly. The aim of pharmacogenomics is to investigate the genetic distribution of the drugs, and to determine the targets of the drugs so as to ensure the optimal efficacy and safety in the clinical practices. It is also used to investigate individual gene characteristics which affect distribution and elimination, and patients' different response to the drug owing to gene variation is also studied. The advancement of pharmacogenomics in pharmacokinetic study was reviewed in this paper. And the polymorphisms of drug metabolizing enzymes and drug transporters were discussed as well. The prospect of its application was also forecast.