TY - JOUR
T1 - Antioxidant action of Guilingji in the brain of rats with FeCl3-induced epilepsy
AU - Liu, Jiankang
AU - Edamatsu, Rei
AU - Kabuto, Hideaki
AU - Mori, Akitane
PY - 1990
Y1 - 1990
N2 - The effects of Guilingji, an antiaging prescription comprised of traditional Chinese medicinal herbs and animal components, on the brain level of thiobarbituric acid reactive substances (TBARS) and superoxide dismutase (SOD) activity in the brain of rats with FeCl3-induced epilepsy were examined with fluorophotometry and electron spin resonance (ESR) spectrometry, respectively. The results showed that pretreatment of rats with Guilingji decreased the levels of TBARS in the left cortex, midbrain, and olfactory lobe, and increased the SOD activity in the midbrain and hypothalamus. These results are the first to demonstrate that Guilingji may possess an antiepileptic effect further to its proposed antiaging action, because decreasing the TBARS elevation and increasing the SOD attenuation in the brain are suggested to be important characteristics of antiepileptic agents. These results suggest that both the proposed antiaging and antiepileptic effects of Guilingji may operate through the mechanism of antioxidation.
AB - The effects of Guilingji, an antiaging prescription comprised of traditional Chinese medicinal herbs and animal components, on the brain level of thiobarbituric acid reactive substances (TBARS) and superoxide dismutase (SOD) activity in the brain of rats with FeCl3-induced epilepsy were examined with fluorophotometry and electron spin resonance (ESR) spectrometry, respectively. The results showed that pretreatment of rats with Guilingji decreased the levels of TBARS in the left cortex, midbrain, and olfactory lobe, and increased the SOD activity in the midbrain and hypothalamus. These results are the first to demonstrate that Guilingji may possess an antiepileptic effect further to its proposed antiaging action, because decreasing the TBARS elevation and increasing the SOD attenuation in the brain are suggested to be important characteristics of antiepileptic agents. These results suggest that both the proposed antiaging and antiepileptic effects of Guilingji may operate through the mechanism of antioxidation.
KW - Antiepileptic, Antiaging
KW - Guilingji, Thiobarbituric acid reactive substances (TBARS), Superoxide dismutase (SOD), Free radicals
UR - https://www.scopus.com/pages/publications/0025611305
U2 - 10.1016/0891-5849(90)90023-C
DO - 10.1016/0891-5849(90)90023-C
M3 - 文章
C2 - 2292438
AN - SCOPUS:0025611305
SN - 0891-5849
VL - 9
SP - 451
EP - 454
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
IS - 5
ER -