Antibacterial and antioxidant supramolecular nanocomposite hydrogel dressings with angiogenesis and photo-thermal effect for multidrug‐resistant bacterial infected wound healing

Antioxidant, antibacterial and removable supramolecular nanocomposite hydrogel dressings with self-healing and tissue adhesiveness is highly anticipated for bacterial infected skin wound healing. A series of supramolecular nanocomposite hydrogels via quadruple hydrogen bond and coordination bonds (catechol-Cu) was developed based on ureidopyrimidinone-modified poly(glycerol sebacate)–co-poly(ethylene glycol)-g-catechol (PEGSDU) and mesoporous copper sulfide nanoparticle (CuS NPs) as antioxidative, antibacterial, removable and tissue-adhesive dressing to treat the MRSA-infected wound. The hydrogels exhibited good self-healing, free radical scavenging, photothermal sterilization performance, adhesiveness, and temperature-sensitive removability. In addition, the Cu²⁺ was able to be slowly released from the hydrogel, which can promote the proliferation and migration of fibroblasts. Hydrogels containing CuS NPs showed better wound repair efficiency than commercial Tegaderm^TM films and hydrogels without CuS NPs in MRSA-infected skin wound, which was attributed to the good antibacterial property, improved collagen deposition, reduced inflammatory response, and improved new vessels formation, thereby significantly promoting the repair of wounds. In summary, this antioxidative and antibacterial supramolecular nanocomposite hydrogel dressing provide a new type of multi-functional dressing for the treatment of infected skin wounds.