Analyzing HLA haplotype of the loci HLA-A, -B, and -DRB1 in mongolia ethnic group

Objective: To investigate HLA-A,-B and -DRB1 allele and HLA-A-B-DRB1 haplotype frequencies in Mongolia ethnic group. Methods: HLA-A, -B, -DRB1 allele and haplotype in the Mongolia ethnic group were investigated based on 93 individuals by PCR- sequence-based typing (SBT) method. Results: Twenty-one alleles were detected for HLA-A, 44 for HLA-B, and 26 for HLA-DRB1. The most frequent alleles were HLA-A * 2402(0.2097), HLA-B * 1302(0.0699), and HLA-DRB1 * 0701 (0.1237). The most common HLA-A-B-DRB1 haplotype were A * 3001-B * 1302-DRB1 * 0701, A * 0101-B * 3701-DRB1 * 1001, followed by the A * 0201-B * 4601-DRB1 * 0901, A * 2402-B * 4801-DRB1 * 1101, A * 2402-B * 5201-DRB1 * 1501, A * 3201-B * 3503-DRB1 * 1301, and A * 3303-B * 5801-DRB1 * 0301, which were also presented in Chinese populations. Conclusion: The data can be used in forensic and paternity tests to estimate the frequency of a DNA profile or anthropologic research. The characteristics of the distribution of HLA alleles revealed that Mongolia ethnic group is characterized by northern Mongolian Chinese.