TY - GEN
T1 - Analysis of ultrafast laser propagation in biological tissues with embedded tumors and large blood vessels
AU - Zhou, Jianhua
AU - Zhang, Yuwen
AU - Chen, J. K.
PY - 2006
Y1 - 2006
N2 - Time-resolved optical imaging technique offers the promise for development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. However, the presence of mismatched refractive-index boundaries in a soft tissue will tremendously change light propagation path, which in turn, makes the optical image obscure if not indiscernible. In this article, a time-resolved Monte Carlo model, which takes into account the photon reflection/transmission behavior at the mismatched refractive-index boundaries, is developed to investigate transient light propagation in biological tissues with embedded tumors and blood vessels. The results show that the temporal reflection signal displays two peak values when refractive-index mismatched foreign objects, such as tumors or blood vessels, are embedded in the tissue. One peak is a direct result arising from the pulse nature of the incident laser light, and the other is due to the backscattering from the refractive-index mismatched boundaries. This suggests that the occurrence of the "second peak" be an indication for the location and size of tumors inside the tissue.
AB - Time-resolved optical imaging technique offers the promise for development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. However, the presence of mismatched refractive-index boundaries in a soft tissue will tremendously change light propagation path, which in turn, makes the optical image obscure if not indiscernible. In this article, a time-resolved Monte Carlo model, which takes into account the photon reflection/transmission behavior at the mismatched refractive-index boundaries, is developed to investigate transient light propagation in biological tissues with embedded tumors and blood vessels. The results show that the temporal reflection signal displays two peak values when refractive-index mismatched foreign objects, such as tumors or blood vessels, are embedded in the tissue. One peak is a direct result arising from the pulse nature of the incident laser light, and the other is due to the backscattering from the refractive-index mismatched boundaries. This suggests that the occurrence of the "second peak" be an indication for the location and size of tumors inside the tissue.
UR - https://www.scopus.com/pages/publications/85196527422
U2 - 10.1115/IMECE2006-13791
DO - 10.1115/IMECE2006-13791
M3 - 会议稿件
AN - SCOPUS:85196527422
SN - 0791837904
SN - 9780791837900
T3 - American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
BT - Proceedings of 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006 - Heat Transfer
PB - American Society of Mechanical Engineers (ASME)
T2 - 2006 ASME International Mechanical Engineering Congress and Exposition, IMECE2006
Y2 - 5 November 2006 through 10 November 2006
ER -