An innovative osteo-regenerator based on beta-tricalcium phosphate granules for bone tissue engineering

Drawbacks in traditional treatments of bone defects with autograft and allograft have prompted the exploration of tissue engineering. Bone tissue engineering generally needs exoteric cells and other growth factors and often unable to regenerate bone with the vascularization and hierarchical organization in native bone. The aim of this study was to establish an osteo-regenerator based on Beta-Tricalcium Phosphate granules which could generate bone without application of exoteric cells and growth factors. In this study, we established an ostoe-regenerator using /3-Tricalcium Phosphate granules in 1 mm-2.5 mm as the scaffold. We drilled two perforative holes in the femur of New Zealand rabbit before fixation. Two titanium alloy shields were applied to fix the whole osteo-regenerator in the femur. At 12 weeks after implantation, the osteo-regenerator was found occupied with abundant new bone. 6.9 eanwe h ri i cle, the connective tissue was seldom observed in the osteo-regenerator. This study has demonstrated that this novel osteo-regenerator can facilitate the new bone generation without any application of other exoteric cells and growth factors and can potentially serves as treatment in bone defect.