TY - GEN
T1 - An all-in-one paper-based microfluidic device for multiplexed detection of cardiac protein markers
AU - Fu, Hao
AU - Li, Xiao
AU - Qin, Zhen
AU - Liu, Xinyu
N1 - Publisher Copyright:
© 2019 CBMS-0001.
PY - 2019
Y1 - 2019
N2 - This paper introduces an electrochemical microfluidic paper-based analytical device (E-µPAD) with an origami architecture, integrating all features (blood filtration, blotting, and impedance-based protein sensing) required for rapid (<50 min) and multiplexed detection of three cardiac protein markers (cardiac troponin I-cTnI, BNP-32, and D-dimer) in human whole blood. We demonstrate ultralow limits of detection (LODs) of 190 fM, 40 fM, and 730 fM for cardiac troponin I (cTnI), BNP-32, and D-dimer in real human blood samples, respectively.
AB - This paper introduces an electrochemical microfluidic paper-based analytical device (E-µPAD) with an origami architecture, integrating all features (blood filtration, blotting, and impedance-based protein sensing) required for rapid (<50 min) and multiplexed detection of three cardiac protein markers (cardiac troponin I-cTnI, BNP-32, and D-dimer) in human whole blood. We demonstrate ultralow limits of detection (LODs) of 190 fM, 40 fM, and 730 fM for cardiac troponin I (cTnI), BNP-32, and D-dimer in real human blood samples, respectively.
KW - All-in-one design
KW - Cardiac markers
KW - Paper-based microfluidics
KW - Point-of-care diagnostics
UR - https://www.scopus.com/pages/publications/85094977260
M3 - 会议稿件
AN - SCOPUS:85094977260
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 82
EP - 83
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -