Alkynylation of Tertiary Cycloalkanols via Radical C-C Bond Cleavage: A Route to Distal Alkynylated Ketones

Shun Wang; Li Na Guo; Hua Wang; Xin Hua Duan

doi:10.1021/acs.orglett.5b02353

Alkynylation of Tertiary Cycloalkanols via Radical C-C Bond Cleavage: A Route to Distal Alkynylated Ketones

Shun Wang
, Li Na Guo
, Hua Wang
, Xin Hua Duan

化学学院

Xi'an Jiaotong University

科研成果: 期刊稿件 › 文章 › 同行评审

125 引用（Scopus）

摘要

An efficient Na₂S₂O₈-promoted radical coupling of tertiary cycloalkanols with alkynyl hypervalent iodide reagents via C-C bond cleavage was developed. This tandem ring-opening/alkynylation procedure showed some advantages, including mild conditions and wide substrate scope, thus providing a simple synthetic method for β-, γ- and δ-alkynylated ketones.

源语言	英语
页（从-至）	4798-4801
页数	4
期刊	Organic Letters
卷	17
期	19
DOI	https://doi.org/10.1021/acs.orglett.5b02353
出版状态	已出版 - 2 10月 2015

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10.1021/acs.orglett.5b02353

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title = "Alkynylation of Tertiary Cycloalkanols via Radical C-C Bond Cleavage: A Route to Distal Alkynylated Ketones",

abstract = "An efficient Na2S2O8-promoted radical coupling of tertiary cycloalkanols with alkynyl hypervalent iodide reagents via C-C bond cleavage was developed. This tandem ring-opening/alkynylation procedure showed some advantages, including mild conditions and wide substrate scope, thus providing a simple synthetic method for β-, γ- and δ-alkynylated ketones.",

author = "Shun Wang and Guo, \{Li Na\} and Hua Wang and Duan, \{Xin Hua\}",

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T2 - A Route to Distal Alkynylated Ketones

AU - Wang, Shun

AU - Guo, Li Na

AU - Wang, Hua

AU - Duan, Xin Hua

PY - 2015/10/2

Y1 - 2015/10/2

N2 - An efficient Na2S2O8-promoted radical coupling of tertiary cycloalkanols with alkynyl hypervalent iodide reagents via C-C bond cleavage was developed. This tandem ring-opening/alkynylation procedure showed some advantages, including mild conditions and wide substrate scope, thus providing a simple synthetic method for β-, γ- and δ-alkynylated ketones.

AB - An efficient Na2S2O8-promoted radical coupling of tertiary cycloalkanols with alkynyl hypervalent iodide reagents via C-C bond cleavage was developed. This tandem ring-opening/alkynylation procedure showed some advantages, including mild conditions and wide substrate scope, thus providing a simple synthetic method for β-, γ- and δ-alkynylated ketones.

UR - https://www.scopus.com/pages/publications/84942891467

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DO - 10.1021/acs.orglett.5b02353

M3 - 文章

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SN - 1523-7060

VL - 17

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Alkynylation of Tertiary Cycloalkanols via Radical C-C Bond Cleavage: A Route to Distal Alkynylated Ketones

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