TY - JOUR
T1 - A novel gastric ulcer model in rats using filter paper with acetic acid
AU - Dong, Siyuan
AU - Wang, Xudong
AU - Liu, Yixin
AU - Qiao, Lu
AU - Xue, Qiong
AU - Zhou, Yixin
AU - Xu, Zhao
AU - Chen, Qun
AU - Chen, Chen
AU - Liu, Na
AU - Wang, Jinhai
N1 - Publisher Copyright:
© 2025 Dong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2025/4
Y1 - 2025/4
N2 - Gastric ulcer animal models are essential for research, but conventional acetic acid-based methods are limited by technical complexity, prolonged modeling duration, and poor applicability for solid anti-ulcer drug testing. This study described a novel and simplified method for inducing gastric ulcers in rats using filter paper imbued with acetic acid. The method provided consistent ulcer formation with uniform size and shape, allowing for targeted drug efficacy testing. Results indicated that the 75% acetic acid concentration yielded the most clinically relevant gastric ulcer model, completed ulcer forming within a day and healing visible after seven days. In conclusion, this model closely replicates human gastric ulcers and is well-suited for preclinical testing of anti-ulcer drugs.
AB - Gastric ulcer animal models are essential for research, but conventional acetic acid-based methods are limited by technical complexity, prolonged modeling duration, and poor applicability for solid anti-ulcer drug testing. This study described a novel and simplified method for inducing gastric ulcers in rats using filter paper imbued with acetic acid. The method provided consistent ulcer formation with uniform size and shape, allowing for targeted drug efficacy testing. Results indicated that the 75% acetic acid concentration yielded the most clinically relevant gastric ulcer model, completed ulcer forming within a day and healing visible after seven days. In conclusion, this model closely replicates human gastric ulcers and is well-suited for preclinical testing of anti-ulcer drugs.
UR - https://www.scopus.com/pages/publications/105002816065
U2 - 10.1371/journal.pone.0319096
DO - 10.1371/journal.pone.0319096
M3 - 文章
C2 - 40233037
AN - SCOPUS:105002816065
SN - 1932-6203
VL - 20
JO - PLoS ONE
JF - PLoS ONE
IS - 4 April
M1 - e0319096
ER -