A facile one-pot synthesis of acrylated hyaluronic acid

A. Sigen; Qian Xu; Peter McMichael; Yongsheng Gao; Xiaolin Li; Xi Wang; Udo Greiser; Dezhong Zhou; Wenxin Wang

doi:10.1039/c7cc08648b

A facile one-pot synthesis of acrylated hyaluronic acid

A. Sigen
, Qian Xu
, Peter McMichael
, Yongsheng Gao
, Xiaolin Li
, Xi Wang
, Udo Greiser
, Dezhong Zhou
, Wenxin Wang

科研成果: 期刊稿件 › 文章 › 同行评审

25 引用（Scopus）

摘要

The synthesis of acrylated hyaluronic acid (HA-A) normally requires 2 to 3 steps of modification, needs laborious purification and also increases the risks of HA degradation. Here, we report that the conjugation of acrylate groups to hyaluronic acid can be successfully achieved via a new facile one-pot approach. Two types of new HA-A hydrogels (via chemical or UV crosslinking) were developed and applied for 3D cell encapsulation.

源语言	英语
页（从-至）	1081-1084
页数	4
期刊	Chemical Communications
卷	54
期	9
DOI	https://doi.org/10.1039/c7cc08648b
出版状态	已出版 - 2018
已对外发布	是

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AU - Sigen, A.

AU - Xu, Qian

AU - McMichael, Peter

AU - Gao, Yongsheng

AU - Li, Xiaolin

AU - Wang, Xi

AU - Greiser, Udo

AU - Zhou, Dezhong

AU - Wang, Wenxin

PY - 2018

Y1 - 2018

N2 - The synthesis of acrylated hyaluronic acid (HA-A) normally requires 2 to 3 steps of modification, needs laborious purification and also increases the risks of HA degradation. Here, we report that the conjugation of acrylate groups to hyaluronic acid can be successfully achieved via a new facile one-pot approach. Two types of new HA-A hydrogels (via chemical or UV crosslinking) were developed and applied for 3D cell encapsulation.

AB - The synthesis of acrylated hyaluronic acid (HA-A) normally requires 2 to 3 steps of modification, needs laborious purification and also increases the risks of HA degradation. Here, we report that the conjugation of acrylate groups to hyaluronic acid can be successfully achieved via a new facile one-pot approach. Two types of new HA-A hydrogels (via chemical or UV crosslinking) were developed and applied for 3D cell encapsulation.

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A facile one-pot synthesis of acrylated hyaluronic acid

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