TY - JOUR
T1 - A conformable phased-array ultrasound patch for bladder volume monitoring
AU - Zhang, Lin
AU - Marcus, Colin
AU - Lin, Dabin
AU - Mejorado, David
AU - Schoen, Scott Joseph
AU - Pierce, Theodore T.
AU - Kumar, Viksit
AU - Fernandez, Sara V.
AU - Hunt, David
AU - Li, Qian
AU - Shuvo, Ikra Iftekhar
AU - Sadat, David
AU - Du, Wenya
AU - Edenbaum, Hannah
AU - Jin, Li
AU - Liu, Weiguo
AU - Eldar, Yonina C.
AU - Li, Fei
AU - Chandrakasan, Anantha P.
AU - Samir, Anthony E.
AU - Dagdeviren, Canan
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2024/1
Y1 - 2024/1
N2 - Ultrasound can be used to image soft tissues in vivo for the early diagnosis and monitoring of disease progression. However, conventional ultrasound probes are rigid, have a narrow field of view and are operator dependent. Conformable transducers have been proposed, but they lack efficient element localization and effective spatial resolution during mechanical deformations. Here we report a conformable ultrasound bladder patch that is based on multiple phased arrays embedded in a stretchable substrate and can provide mechanically robust, conformable and in vivo volumetric organ monitoring. The phased arrays use Sm/La-doped Pb(Mg1/3Nb2/3)O3–PbTiO3 ceramics as the piezoelectric material, which offers superior properties (d 33 = 1,000 pC N−1, ε r = 7,500 and k 33 = 0.77) than conventional piezoelectric ceramics. We use the conformable ultrasound patch in a pilot clinical study of bladder monitoring. Bladder volume estimation with the patch is comparable (relative errors of 3.2 ± 6.4% and 10.8 ± 8.2% with and without ultrasound gel, respectively) to that obtained using standard clinical ultrasound equipment, and not requiring manual translation or rotation by an operator.
AB - Ultrasound can be used to image soft tissues in vivo for the early diagnosis and monitoring of disease progression. However, conventional ultrasound probes are rigid, have a narrow field of view and are operator dependent. Conformable transducers have been proposed, but they lack efficient element localization and effective spatial resolution during mechanical deformations. Here we report a conformable ultrasound bladder patch that is based on multiple phased arrays embedded in a stretchable substrate and can provide mechanically robust, conformable and in vivo volumetric organ monitoring. The phased arrays use Sm/La-doped Pb(Mg1/3Nb2/3)O3–PbTiO3 ceramics as the piezoelectric material, which offers superior properties (d 33 = 1,000 pC N−1, ε r = 7,500 and k 33 = 0.77) than conventional piezoelectric ceramics. We use the conformable ultrasound patch in a pilot clinical study of bladder monitoring. Bladder volume estimation with the patch is comparable (relative errors of 3.2 ± 6.4% and 10.8 ± 8.2% with and without ultrasound gel, respectively) to that obtained using standard clinical ultrasound equipment, and not requiring manual translation or rotation by an operator.
UR - https://www.scopus.com/pages/publications/85176741379
U2 - 10.1038/s41928-023-01068-x
DO - 10.1038/s41928-023-01068-x
M3 - 文章
AN - SCOPUS:85176741379
SN - 2520-1131
VL - 7
SP - 77
EP - 90
JO - Nature Electronics
JF - Nature Electronics
IS - 1
ER -