聚硫辛酸基多功能水凝胶的构建及在感染皮肤伤口修复中的应用

Poly(lipoic acid)-based functional hydrogels incorporated with silver nanoparticles (AgNPs) are developed for bacteria-infected skin wound healing in this work. Owing to the reducibility of α-lipoic acid (LA), AgNO₃ can be converted into AgNPs in the local hydrogel network (PLAS@AgNPs hydrogels), which are synthesized by concentration- and thermo-induced ring-opening polymerization of LA in the presence of NaHCO₃. Benefiting from the dynamic nature of hydrogen bonds formed by －COOH groups, PLAS@AgNPs hydrogels feature facile injectability and self-healing ability, and exhibit stable adhesion behavior with porcine skin tissues (36 kPa). The resulting hydrogels show promising photothermal efficiency due to the in situ formation of AgNPs, and the temperature of the hydrogels can be elevated by 38 ^oC with the irradiation of near-infrared (NIR) light for 10 min, which can effectively inhibit the proliferation of escherichia coli and staphylococcus aureus. Moreover, the PLAS@AgNPs hydrogels can also clear the intracellular reactive oxygen species (ROS) inherited from the antioxidant nature of LA. In a rat full-thickness skin injury model with bacterial infection, the PLAS@AgNPs hydrogel dressing can accelerate the skin wound healing with the assistance of NIR light irradiation through the synergistic effect of anti-bacteria and ROS scavenging.