纤维蛋白原与心肌缺血再灌注损伤患者炎症反应的相关性分析

Objective: To investigate the correlation between fibrinogen (FIB) and early inflammatory response in patients with myocardial ischemia/reperfusion injury (MIRI) so as to explore the role of FIB in predicting early inflammation during MIRI. Methods: Patients with acute myocardial infarction were treated by coronary angiography (CAG) and/or percutaneous coronary intervention (PCI) according to their conditions, and MIRI was induced by PCI. Blood samples were collected before and 2 hours after operation. FIB, creatine kinase-MB (CK-MB), troponin I (cTnI), tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) and macrophage migration inhibitory factor (MIF) in the plasma were measured by enzyme-linked immunosorbent assay. Patients subjected with PCI were divided into three subgroups according to the level of plasma FIB; the correlation between FIB and the above-mentioned inflammatory cytokines was evaluated in the patients subjected to MIRI. Results: The levels of serum FIB, CK-MB and cTnI in the patients subjected to PCI were higher than those in patients subjected to CAG (P<0.05 or P<0.01). Compared with patients in CAG, inflammatory cytokines including TNF-α, MPO and MIF after PCI were significantly increased (P<0.05). The inflammatory cytokines presented a rising trend with the increase of FIB level, and there was a certain correlation between FIB and inflammatory cytokines (r=0.625, 0.756, 0.864, P<0.01 or P<0.001). Conclusion: Serum inflammatory cytokines are up-regulated after MIRI. There is a certain correlation between FIB and inflammatory cytokines in patients with MIRI. FIB can be regarded as a predictor of inflammation associated with MIRI.