等离子体的抗癌效应及其生物学机制

Cold atmospheric plasma generates multiple reactive species, which can selectively inhibit cancer cells without harming normal cells under appropriate treatment conditions via inducing oxidative stress and metabolism disorder in cancer cells and programmed cell death for cancer cells. In addition, cold atmospheric plasma can further activate the immune system to recognize and eliminate cancer cells, thus making it a promising method of precision cancer therapy. Here we systematically review the research progress of plasma in-situ, bystander, and distal anticancer effects, and focus on the different application forms of plasma, the multiple forms of anticancer effects with related biological mechanisms, biosafety, and current challenges. Moreover, we explore the development prospects of plasma in meeting clinical needs such as precisely controlled in-situ cancer therapy, efficient immune synergistic cancer therapy, and sensitization of molecular cancer diagnostics in conjunction with existing clinical cancer diagnostic and therapeutic methods so as to serve as a reference for further theoretical and applied research.