磁吻合技术在大鼠全胃切除术后 食管小肠吻合中的应用研究

Objective Digestive tract reconstruction after total gastrectomy is complicated and causes many complications. This study aimed to investigate the feasibility, safety and effectiveness of magnetic compression anastomosis (MCA) for sutureless reconstruction after total gastrectomy in rats. Methods Twenty-four rats were randomly apportioned to two groups. Reconstruction was performed with MCA in the experimental group or hand-sewn in the control group, and the construction time was recorded. The animals were followed up for 30 days. The survival rate and complications were monitored. At each time point, the rats were euthanized to study the gross/ histological morphology and mechanical strength of the anastomoses. Results The reconstruction time was (12.9 + 2.7)min in the experimental group and (23.8 + 4.1)min in the control group (P; 0.036).In the experimental group, there was no anastomotic complication. Four control rats developed anastomotic leakage or hemorrhage, and all died within 4 postoperative days. Compared with the control group, burst pressure in the experimental group was similar. Both groups' anastomoses had smooth gross appearance and histologically good alignment of tissue layers. Conclusion MCA is a safe and effective choice for reconstruction after total gastrectomy, with better postoperative outcomes than hand-sewn.