慢 性 阻 塞 性 肺 疾 病 与 房 颤 及 房 扑 因 果 关 系 的孟 德 尔 随 机 化 研 究

Objective: To investigate the potential causal relationship between chronic obstructive pulmonary disease (COPD) and the risk of atrial fibrillation/flutter by using a two-sample Mendelian randomization (MR) approach. Methods: The study data were obtained from summary statistics of genome-wide association studies (GWAS), with 3 871 COPD cases and 5 669 atrial fibrillation/flutter cases included. A total of seventeen genetic variants that are closely associated with COPD were selected as instrumental variables. MR analysis was carried out by inverse variance weighted, weighted median, and MR-Egger methods, respectively. MR-Egger test was used to detect horizontal pleiotropy, and the leave-one-out sensitivity analysis was conducted to ensure result robustness. Results: The inverse variance weighted analysis showed a significant positive correlation between COPD and the risk of atrial fibrillation/flutter (OR=1. 227, 95%CI:1. 024-1. 470, P=0. 027). The weighted median method produced similar results (OR=1. 209, 95%CI:1. 008-1. 450, P=0. 041). In the sensitivity analysis, the MR-Egger test with a P-value of 0. 65 suggests the absence of horizontal pleiotropy. Furthermore, the Leave-one-out analysis did not identify any influential SNPs significantly affecting the results. Conclusion: This study suggests that there may be a positive causal relationship between COPD and the risk of atrial fibrillation/flutter.