弧形变截面微通道内颗粒富集的实验研究

The efficient enrichment of microparticles in microchannels has significant application value in fields such as biomedicine. For example, the efficient enrichment of target cells in blood can help improve the accuracy of microfluidic chip technology detection. Arc-shaped microchannels are an effective way to manipulate the motion of microparticles due to their ability to induce Dean drag forces. In the Newtonian fluid of arc-shaped microchannels, microparticles are mainly enriched at specific equilibrium positions in the microchannels due to the combined action of inertial lift forces and Dean drag forces. Effectively controlling the enrichment position of microparticles in microchannels is crucial for subsequent efficient and accurate detection. In this study, a series of sharp-angled microstructures were introduced in the arc-shaped microchannels to change the forces acting on the particles, ultimately achieving effective control of particle enrichment positions. The research found that the position of the sharp-angled structures and flow parameters have a significant impact on the equilibrium position of the particles, causing the particles’ equilibrium position to deviate towards the side of the sharp-angled structures.