受教育程度与胰腺炎的因果关系:一项孟德尔随机化研究

Objective To explore the causal relationship between education level and pancreatitis risk through Mendelian randomization. Methods A two-sample Mendelian randomization analysis was conducted using genome-wide association study (GWAS) summary data. The GWAS data for education level and pancreatitis were obtained from SSGAC database and the FinnGen database (version R9). Causal relationship between education level and pancreatitis was explored using the inverse variance weighted (IVW), MR-Egger, and weighted median methods. Heterogeneity and directional pleiotropy were evaluated using Cochran's Q test and funnel plots. Results Totally 604 SNPs associated with education level were included. The results provided evidence that there was negative relationship between education level and pancreatitis risk. For acute pancreatitis, OR =0.52, 95% CI % 0.44 — 0.62, P = 2.43X10~U while for chronic pancreatitis, OR = 0.51, 95% CI ■. 0.41 - 0.64, P = 7.20X10~9. Results from MR-Egger and weighted median analyses obtained the same results. The results of sensitivity analysis indicated that this study did not violate the basic assumptions of Mendelian randomization. Conclusion There is a causal relationship between education level and the occurrence of pancreatitis. The educational level is negatively correlated with the risk of pancreatitis.