免疫细胞与慢性胰腺炎之间的因果关系:一项双向孟德尔随机化分析

Objective To explore the casual relationship between immune cells and chronic pancreatitis (CP) using Mendelian randomization (MR) analysis. Methods The immune cell phenotypes and CP GWAS data used in this study were obtained from public databases, and 731 immune cell phenotypes were included. The bidirectional MR analysis was used to explore the causal relationship between immune cells and CP, and various sensitivity analysis methods were used to verify the heterogeneity and level multiplicity of the results. Results This study identified 33 immune cell phenotypes with a causal relationship with CP, of which 18 were inhibitory factors, and the rest were risk factors. Among the 18 inhibitory factors, CD25 on CD4+ in the Treg cell group showed the most significant inhibitory effect. Among the 15 risk factors, CD8br AC in the TBNK cell group, CD8br on TD CD8br in the mature T cell group, and CD39+ CD8br %T cell and CD28 on CD4+ in the Treg cell group showed statistical significance. The reverse MR results further confirmed the unidirectionality of the causal relationship. Conclusion Our study revealed the close relationship between immune cells and CP through MR method, highlighting the complex interaction pattern between the immune system and CP.