Zinc distribution in mouse brain by SRXRF

Zhang Yuanxun; Zhang Yongping; Li Delu; Zhang Guilin; Long Jiangang; Shen Hui; Huang Yuying; He Wei

doi:10.1007/s10967-006-0222-6

Zinc distribution in mouse brain by SRXRF

Zhang Yuanxun
, Zhang Yongping
, Li Delu
, Zhang Guilin
, Long Jiangang
, Shen Hui
, Huang Yuying
, He Wei

Chinese Academy of Sciences
Naval Medical University
CAS - Institute of High Energy Physics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In order to explore the interaction between the expression of ZnT3 (Zinc Transporter 3) mRNA (Messenger Ribonucleic Acid) and the concentration of elemental zinc in mouse brain, zinc distribution in brain was determined by synchrotron radiation X-ray fluorescence (SRXRF) technique and a ZnT3 mRNA expression in tissue was examined by the reverse-transcriptase polymerase chain reaction (RT-PCR) method. The results show that the zinc concentration is not evenly distributed in brain slices. Its concentrations in cerebral cortex and hippocampus are nearly 5-10 times higher than those in other positions. A corresponding relation is that ZnT3 mRNA in cerebral cortex, hippocampus and testis has higher abundant degree, but it is not examined out in other tissues. Furthermore, the results promote that ZnT3 facilitates the accumulation of zinc in synaptic vesicles and may play an important role in structuring of vesicular zinc pool.

Original language	English
Pages (from-to)	235-239
Number of pages	5
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	269
Issue number	1
DOIs	https://doi.org/10.1007/s10967-006-0222-6
State	Published - Jul 2006
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/s10967-006-0222-6

Cite this

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title = "Zinc distribution in mouse brain by SRXRF",

abstract = "In order to explore the interaction between the expression of ZnT3 (Zinc Transporter 3) mRNA (Messenger Ribonucleic Acid) and the concentration of elemental zinc in mouse brain, zinc distribution in brain was determined by synchrotron radiation X-ray fluorescence (SRXRF) technique and a ZnT3 mRNA expression in tissue was examined by the reverse-transcriptase polymerase chain reaction (RT-PCR) method. The results show that the zinc concentration is not evenly distributed in brain slices. Its concentrations in cerebral cortex and hippocampus are nearly 5-10 times higher than those in other positions. A corresponding relation is that ZnT3 mRNA in cerebral cortex, hippocampus and testis has higher abundant degree, but it is not examined out in other tissues. Furthermore, the results promote that ZnT3 facilitates the accumulation of zinc in synaptic vesicles and may play an important role in structuring of vesicular zinc pool.",

author = "Zhang Yuanxun and Zhang Yongping and Li Delu and Zhang Guilin and Long Jiangang and Shen Hui and Huang Yuying and He Wei",

year = "2006",

month = jul,

doi = "10.1007/s10967-006-0222-6",

language = "英语",

volume = "269",

pages = "235--239",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Zinc distribution in mouse brain by SRXRF

AU - Yuanxun, Zhang

AU - Yongping, Zhang

AU - Delu, Li

AU - Guilin, Zhang

AU - Jiangang, Long

AU - Hui, Shen

AU - Yuying, Huang

AU - Wei, He

PY - 2006/7

Y1 - 2006/7

N2 - In order to explore the interaction between the expression of ZnT3 (Zinc Transporter 3) mRNA (Messenger Ribonucleic Acid) and the concentration of elemental zinc in mouse brain, zinc distribution in brain was determined by synchrotron radiation X-ray fluorescence (SRXRF) technique and a ZnT3 mRNA expression in tissue was examined by the reverse-transcriptase polymerase chain reaction (RT-PCR) method. The results show that the zinc concentration is not evenly distributed in brain slices. Its concentrations in cerebral cortex and hippocampus are nearly 5-10 times higher than those in other positions. A corresponding relation is that ZnT3 mRNA in cerebral cortex, hippocampus and testis has higher abundant degree, but it is not examined out in other tissues. Furthermore, the results promote that ZnT3 facilitates the accumulation of zinc in synaptic vesicles and may play an important role in structuring of vesicular zinc pool.

AB - In order to explore the interaction between the expression of ZnT3 (Zinc Transporter 3) mRNA (Messenger Ribonucleic Acid) and the concentration of elemental zinc in mouse brain, zinc distribution in brain was determined by synchrotron radiation X-ray fluorescence (SRXRF) technique and a ZnT3 mRNA expression in tissue was examined by the reverse-transcriptase polymerase chain reaction (RT-PCR) method. The results show that the zinc concentration is not evenly distributed in brain slices. Its concentrations in cerebral cortex and hippocampus are nearly 5-10 times higher than those in other positions. A corresponding relation is that ZnT3 mRNA in cerebral cortex, hippocampus and testis has higher abundant degree, but it is not examined out in other tissues. Furthermore, the results promote that ZnT3 facilitates the accumulation of zinc in synaptic vesicles and may play an important role in structuring of vesicular zinc pool.

UR - https://www.scopus.com/pages/publications/33746438817

U2 - 10.1007/s10967-006-0222-6

DO - 10.1007/s10967-006-0222-6

M3 - 文章

AN - SCOPUS:33746438817

SN - 0236-5731

VL - 269

SP - 235

EP - 239

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 1

ER -

Zinc distribution in mouse brain by SRXRF

Abstract

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