TY - JOUR
T1 - Yolk-shell polyphosphazenes nanotheranostics for multimodal imaging guided effective phototherapy
AU - Yan, Kai
AU - Mu, Chenglong
AU - Wang, Daquan
AU - Jing, Xunan
AU - Zhang, Ning
AU - Meng, Lingjie
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - A critical issue of photodynamic therapy (PDT) is the hypoxia feature in tumor microenvironment and the PDT-caused continuous oxygen consumption, which suppresses the effect of tumor treatment. Though the perfluorocarbon-based microbubbles with high oxygen affinity have been utilized to supply endogenous oxygen to improve PDT, some risks are wished to be addressed including oxygen leakage and storage issues. Herein, perfluorohexane (PFH) and Fe3O4 nanoparticles were encapsulated in biocompatible polyphosphazenes (PPZ) and polydopamine (PDA) shells were further grown to prevent the leakage of PFH. After loading chlorine e6 (Ce6) and modifying with polyethylene glycol (PEG), a multimodal nanotheranostic (PFH–Fe3O4@PPZ@PDA-PEG-Ce6) were successfully constructed for ultrasonic (US), magnetic resonance (MR) and fluorescence imaging guided photothermal therapy (PTT) and enhanced PDT. PFH can not only bind and delivery oxygen but also be used as contrast agent for US imaging. While PDA is a frequently used PTT agent and Ce6 is PDT agent as well as fluorescent agent. The yolk-shell nanoplatform showed good biocompatibility, biostability and well cellular uptake. Importantly, strengthened PDT efficiency has also been greatly improved due to high oxygen-rich PFH. Furthermore, the nanoplatform efficiently generated hyperthermia to kill tumor upon 808 nm illumination. Remarkably, the PTT/enhanced PDT combination therapy can be realized under the guidance of US/MR/fluorescence imaging. This nanoplatform could dramatically inhibit tumor growth by PTT and improved PDT, demonstrating great promising for multimodal imaging guided phototherapy.
AB - A critical issue of photodynamic therapy (PDT) is the hypoxia feature in tumor microenvironment and the PDT-caused continuous oxygen consumption, which suppresses the effect of tumor treatment. Though the perfluorocarbon-based microbubbles with high oxygen affinity have been utilized to supply endogenous oxygen to improve PDT, some risks are wished to be addressed including oxygen leakage and storage issues. Herein, perfluorohexane (PFH) and Fe3O4 nanoparticles were encapsulated in biocompatible polyphosphazenes (PPZ) and polydopamine (PDA) shells were further grown to prevent the leakage of PFH. After loading chlorine e6 (Ce6) and modifying with polyethylene glycol (PEG), a multimodal nanotheranostic (PFH–Fe3O4@PPZ@PDA-PEG-Ce6) were successfully constructed for ultrasonic (US), magnetic resonance (MR) and fluorescence imaging guided photothermal therapy (PTT) and enhanced PDT. PFH can not only bind and delivery oxygen but also be used as contrast agent for US imaging. While PDA is a frequently used PTT agent and Ce6 is PDT agent as well as fluorescent agent. The yolk-shell nanoplatform showed good biocompatibility, biostability and well cellular uptake. Importantly, strengthened PDT efficiency has also been greatly improved due to high oxygen-rich PFH. Furthermore, the nanoplatform efficiently generated hyperthermia to kill tumor upon 808 nm illumination. Remarkably, the PTT/enhanced PDT combination therapy can be realized under the guidance of US/MR/fluorescence imaging. This nanoplatform could dramatically inhibit tumor growth by PTT and improved PDT, demonstrating great promising for multimodal imaging guided phototherapy.
KW - Multimodal imaging
KW - Photodynamic therapy
KW - Photothermal therapy
KW - Polyphosphazenes
UR - https://www.scopus.com/pages/publications/85122142751
U2 - 10.1016/j.coco.2021.100950
DO - 10.1016/j.coco.2021.100950
M3 - 文章
AN - SCOPUS:85122142751
SN - 2452-2139
VL - 28
JO - Composites Communications
JF - Composites Communications
M1 - 100950
ER -