XRCC1 rs25487 locus genetic polymorphisms and susceptibility to nonobstructive azoospermia in Hui minority ethnic population of Shaanxi province

Objective: To explore the association between X-ray repair cross complementing group 1 (XRCC1) gene rs25487 locus polymorphisms and nonobstructive azoospermia in Hui minority ethic population of Shaanxi Province. Methods: We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method for genotyping at XRCC1 gene rs25487 locus in 79 patients with nonobstructive azoospermia and 82 healthy male controls in Hui minority ethic population of Shaanxi Province. Then we analyzed the association between XRCC1 gene rs25487 locus and nonobstructive azoospermia. Results: Compared with GG genotype, GA, AA and GA+AA genotypes demonstrated a significantly increased risk for nonobstructive azoospermia (OR=2.286, 95% CI 1.151-4.539; OR=2.202, 95% CI 0.753-6.439; OR=2.271, 95% CI 1.171-4.403), respectively. Meanwhile, the A allele frequency was significantly higher in azoospermic patients than in controls (OR=1.582, 95% CI 1.005-2.492, P=0.047). Conclusion: G→A in XRCC1 gene rs25487 locus is correlated with nonobstructive azoospermia in Hui minority ethic population of Shaanxi province.