TY - JOUR
T1 - White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration
AU - Huang, Peiyu
AU - Zhang, Ruiting
AU - Jiaerken, Yeerfan
AU - Wang, Shuyue
AU - Hong, Hui
AU - Yu, Wenke
AU - Lian, Chunfeng
AU - Li, Kaicheng
AU - Zeng, Qingze
AU - Luo, Xiao
AU - Yu, Xinfeng
AU - Wu, Xiao
AU - Xu, Xiaopei
AU - Zhang, Minming
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
PY - 2022/2
Y1 - 2022/2
N2 - To investigate the association between white matter free water (FW) and common imaging markers of cerebral small vessel diseases (CSVD) in two groups of subjects with different clinical status. One hundred and forty-four community subjects (mean age 60.5) and 84 CSVD subjects (mean age 61.2) were retrospectively included in the present study. All subjects received multi-modal magnetic resonance imaging and clinical assessments. The association between white matter FW and common CSVD imaging markers, including white matter hyperintensities (WMH), dilated perivascular space (PVS), lacunes, and microbleeds, were assessed using simple and multiple regression analysis. The association between FW and cognitive scores were also investigated. White matter FW was positively associated with WMH volume (β = 0.270, p = 0.001), PVS volume (β = 0.290, p < 0.001), number of microbleeds (β = 0.148, p = 0.043), and age (β = 0.170, p = 0.036) in the community cohort. In the CSVD cohort, FW was positively associated with WMH volume (β = 0.648, p < 0.001), PVS score (β = 0.224, p < 0.001), number of lacunes (β = 0.140, p = 0.046), and sex (β = 0.125, p = 0.036). The associations between FW and cognitive scores were stronger than conventional CSVD markers in both datasets. White matter FW is a potential composite marker that can sensitively detect cerebral small vessel degeneration and also reflect cognitive impairments.
AB - To investigate the association between white matter free water (FW) and common imaging markers of cerebral small vessel diseases (CSVD) in two groups of subjects with different clinical status. One hundred and forty-four community subjects (mean age 60.5) and 84 CSVD subjects (mean age 61.2) were retrospectively included in the present study. All subjects received multi-modal magnetic resonance imaging and clinical assessments. The association between white matter FW and common CSVD imaging markers, including white matter hyperintensities (WMH), dilated perivascular space (PVS), lacunes, and microbleeds, were assessed using simple and multiple regression analysis. The association between FW and cognitive scores were also investigated. White matter FW was positively associated with WMH volume (β = 0.270, p = 0.001), PVS volume (β = 0.290, p < 0.001), number of microbleeds (β = 0.148, p = 0.043), and age (β = 0.170, p = 0.036) in the community cohort. In the CSVD cohort, FW was positively associated with WMH volume (β = 0.648, p < 0.001), PVS score (β = 0.224, p < 0.001), number of lacunes (β = 0.140, p = 0.046), and sex (β = 0.125, p = 0.036). The associations between FW and cognitive scores were stronger than conventional CSVD markers in both datasets. White matter FW is a potential composite marker that can sensitively detect cerebral small vessel degeneration and also reflect cognitive impairments.
KW - Cerebral small vessel disease
KW - Diffusion tensor imaging
KW - Free water
KW - White matter
UR - https://www.scopus.com/pages/publications/85101777214
U2 - 10.1007/s12975-021-00899-0
DO - 10.1007/s12975-021-00899-0
M3 - 文章
C2 - 33634379
AN - SCOPUS:85101777214
SN - 1868-4483
VL - 13
SP - 56
EP - 64
JO - Translational Stroke Research
JF - Translational Stroke Research
IS - 1
ER -