TY - JOUR
T1 - Water-soluble organic probe for pH sensing and imaging
AU - Wang, Jing
AU - Liu, Hui
AU - Wu, Ming
AU - Liu, Xiaolong
AU - Sun, Haiyan
AU - Zheng, Aixian
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - pH value is one of the most important parameters, which show significant application in environmental monitoring, chemistry and biology. Abnormal pH values always associate with some serious diseases, including cancer and Alzheimer's disease. Thus, development of highly sensitive and selective method for pH sensing and imaging is of great importance. In this paper, we synthesized a water-soluble organic probe for pH sensing either through its absorption or through its fluorescent signals. The probe was synthesized from the intermediate containing a phenol group, and the reaction was carried out in concentrated H2SO4 at 90 °C. In this way, the probe can introduce a sulfonic acid group into its structure, and thus improve its water solubility. The synthesized probe is pH-responsive, and the response process is reversible, because that the phenol group in the probe can transfer to deprotonation state with increasing the pH values to improve the intramolecular charge transfer. Meanwhile, the synthesized probe also showed high specificity and excellent biocompatibility, which is suitable for cell imaging applications.
AB - pH value is one of the most important parameters, which show significant application in environmental monitoring, chemistry and biology. Abnormal pH values always associate with some serious diseases, including cancer and Alzheimer's disease. Thus, development of highly sensitive and selective method for pH sensing and imaging is of great importance. In this paper, we synthesized a water-soluble organic probe for pH sensing either through its absorption or through its fluorescent signals. The probe was synthesized from the intermediate containing a phenol group, and the reaction was carried out in concentrated H2SO4 at 90 °C. In this way, the probe can introduce a sulfonic acid group into its structure, and thus improve its water solubility. The synthesized probe is pH-responsive, and the response process is reversible, because that the phenol group in the probe can transfer to deprotonation state with increasing the pH values to improve the intramolecular charge transfer. Meanwhile, the synthesized probe also showed high specificity and excellent biocompatibility, which is suitable for cell imaging applications.
KW - Fluorescence imaging
KW - Intramolecular charge transfer
KW - pH sensing
KW - Phenol group
UR - https://www.scopus.com/pages/publications/85068370905
U2 - 10.1016/j.talanta.2019.06.095
DO - 10.1016/j.talanta.2019.06.095
M3 - 文章
C2 - 31450452
AN - SCOPUS:85068370905
SN - 0039-9140
VL - 205
JO - Talanta
JF - Talanta
M1 - 120095
ER -
