Ultrasound-enhanced extravasation of multifunctional nanodroplets from leaky vessel

  • Y. J. Zong
  • , Xinru Zou
  • , Rongrong Wang
  • , Yi Feng
  • , Mingxi Wan

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Poorly organized vascular architecture of tumor tissue allows extravasation of drug-loaded nanoparticles through the large interendothelial gaps. Extravasated perfluorocarbon nanodroplets can convert into microbubbles under ultrasound irradiation to imaging or deliver drug for tumor treatment. However an increased interstitial fluid pressure in tumor tissue hinders convectional transport of drug carriers across blood vessel walls, thus extravasation of sufficient amounts of droplets remains a major challenge. In this paper, we propose an ultrasound-enhanced extravasation strategy using synergetic effect of acoustic radiation force and cavitation enhanced penetration.

Original languageEnglish
Title of host publication2015 IEEE International Ultrasonics Symposium, IUS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479981823
DOIs
StatePublished - 13 Nov 2015
EventIEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China
Duration: 21 Oct 201524 Oct 2015

Publication series

Name2015 IEEE International Ultrasonics Symposium, IUS 2015

Conference

ConferenceIEEE International Ultrasonics Symposium, IUS 2015
Country/TerritoryTaiwan, Province of China
CityTaipei
Period21/10/1524/10/15

Keywords

  • acoustic radiation force
  • cavitation
  • extravasation
  • leaky vessel
  • nanodroplets

Fingerprint

Dive into the research topics of 'Ultrasound-enhanced extravasation of multifunctional nanodroplets from leaky vessel'. Together they form a unique fingerprint.

Cite this