UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion

Fan Wang; Xu Li; Xiao Juan Xie; Le Zhao; Wei Chen

doi:10.1016/j.febslet.2008.05.012

UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion

Fan Wang
, Xu Li
, Xiao Juan Xie
, Le Zhao
, Wei Chen

First Affiliated Hospital
Shaanxi Provincial People's Hospital

Research output: Contribution to journal › Article › peer-review

345 Scopus citations

Abstract

A non-protein-coding RNA, UCA1, has been cloned from human bladder TCC cell line BLZ-211 by using 5′ and 3′ RACE. The UCA1 full-length cDNA was 1442 bp. RT-PCR analysis indicated that UCA1 is an embryonic development and bladder cancer-associated RNA. The proliferative, migrative, invasive, and drug resistance behaviors of human bladder TCC cell line BLS-211 were enhanced by exogenous UCA1 expression in vitro. Several potential target genes of UCA1 were identified through microarray analysis. Moreover, the expression of UCA1 also increased tumorigenic potential of BLS-211 cells in nude mice. Results from the present study suggested that UCA1 might play a pivotal role in bladder cancer progression and embryonic development.

Original language	English
Pages (from-to)	1919-1927
Number of pages	9
Journal	FEBS Letters
Volume	582
Issue number	13
DOIs	https://doi.org/10.1016/j.febslet.2008.05.012
State	Published - 11 Jun 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bladder cancer
Development
RACE
SRPK1
UCA1
ncRNA

Access to Document

10.1016/j.febslet.2008.05.012

Cite this

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title = "UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion",

abstract = "A non-protein-coding RNA, UCA1, has been cloned from human bladder TCC cell line BLZ-211 by using 5′ and 3′ RACE. The UCA1 full-length cDNA was 1442 bp. RT-PCR analysis indicated that UCA1 is an embryonic development and bladder cancer-associated RNA. The proliferative, migrative, invasive, and drug resistance behaviors of human bladder TCC cell line BLS-211 were enhanced by exogenous UCA1 expression in vitro. Several potential target genes of UCA1 were identified through microarray analysis. Moreover, the expression of UCA1 also increased tumorigenic potential of BLS-211 cells in nude mice. Results from the present study suggested that UCA1 might play a pivotal role in bladder cancer progression and embryonic development.",

keywords = "Bladder cancer, Development, RACE, SRPK1, UCA1, ncRNA",

author = "Fan Wang and Xu Li and Xie, \{Xiao Juan\} and Le Zhao and Wei Chen",

year = "2008",

month = jun,

day = "11",

doi = "10.1016/j.febslet.2008.05.012",

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volume = "582",

pages = "1919--1927",

journal = "FEBS Letters",

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publisher = "John Wiley and Sons Inc",

number = "13",

}

TY - JOUR

T1 - UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion

AU - Wang, Fan

AU - Li, Xu

AU - Xie, Xiao Juan

AU - Zhao, Le

AU - Chen, Wei

PY - 2008/6/11

Y1 - 2008/6/11

N2 - A non-protein-coding RNA, UCA1, has been cloned from human bladder TCC cell line BLZ-211 by using 5′ and 3′ RACE. The UCA1 full-length cDNA was 1442 bp. RT-PCR analysis indicated that UCA1 is an embryonic development and bladder cancer-associated RNA. The proliferative, migrative, invasive, and drug resistance behaviors of human bladder TCC cell line BLS-211 were enhanced by exogenous UCA1 expression in vitro. Several potential target genes of UCA1 were identified through microarray analysis. Moreover, the expression of UCA1 also increased tumorigenic potential of BLS-211 cells in nude mice. Results from the present study suggested that UCA1 might play a pivotal role in bladder cancer progression and embryonic development.

AB - A non-protein-coding RNA, UCA1, has been cloned from human bladder TCC cell line BLZ-211 by using 5′ and 3′ RACE. The UCA1 full-length cDNA was 1442 bp. RT-PCR analysis indicated that UCA1 is an embryonic development and bladder cancer-associated RNA. The proliferative, migrative, invasive, and drug resistance behaviors of human bladder TCC cell line BLS-211 were enhanced by exogenous UCA1 expression in vitro. Several potential target genes of UCA1 were identified through microarray analysis. Moreover, the expression of UCA1 also increased tumorigenic potential of BLS-211 cells in nude mice. Results from the present study suggested that UCA1 might play a pivotal role in bladder cancer progression and embryonic development.

KW - Bladder cancer

KW - Development

KW - RACE

KW - SRPK1

KW - UCA1

KW - ncRNA

UR - https://www.scopus.com/pages/publications/44449098601

U2 - 10.1016/j.febslet.2008.05.012

DO - 10.1016/j.febslet.2008.05.012

M3 - 文章

C2 - 18501714

AN - SCOPUS:44449098601

SN - 0014-5793

VL - 582

SP - 1919

EP - 1927

JO - FEBS Letters

JF - FEBS Letters

IS - 13

ER -

UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion

Abstract

UN SDGs

Keywords

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