Trehalose-Conjugated, Photofunctionalized Mesoporous Silica Nanoparticles for Efficient Delivery of Isoniazid into Mycobacteria

Juan Zhou; Kalana W. Jayawardana; Na Kong; Yansong Ren; Nanjing Hao; Mingdi Yan; Olof Ramström

doi:10.1021/acsbiomaterials.5b00274

Trehalose-Conjugated, Photofunctionalized Mesoporous Silica Nanoparticles for Efficient Delivery of Isoniazid into Mycobacteria

Juan Zhou
, Kalana W. Jayawardana
, Na Kong
, Yansong Ren
, Nanjing Hao
, Mingdi Yan
, Olof Ramström

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Glyconanoparticle carriers have been synthesized and efficiently delivered into mycobacteria. Mesoporous silica nanoparticles were functionalized with α,α-trehalose through azide-mediated surface photoligation, and loaded with the antitubercular drug isoniazid. The glyconanoparticles showed high isoniazid loading capacity and higher antimicrobial activity than the free drug.

Original language	English
Pages (from-to)	1250-1255
Number of pages	6
Journal	ACS Biomaterials Science and Engineering
Volume	1
Issue number	12
DOIs	https://doi.org/10.1021/acsbiomaterials.5b00274
State	Published - 14 Dec 2015
Externally published	Yes

Keywords

drug delivery
isoniazid
mesoporous silica nanoparticle
trehalose

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10.1021/acsbiomaterials.5b00274

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title = "Trehalose-Conjugated, Photofunctionalized Mesoporous Silica Nanoparticles for Efficient Delivery of Isoniazid into Mycobacteria",

abstract = "Glyconanoparticle carriers have been synthesized and efficiently delivered into mycobacteria. Mesoporous silica nanoparticles were functionalized with α,α-trehalose through azide-mediated surface photoligation, and loaded with the antitubercular drug isoniazid. The glyconanoparticles showed high isoniazid loading capacity and higher antimicrobial activity than the free drug.",

keywords = "drug delivery, isoniazid, mesoporous silica nanoparticle, trehalose",

author = "Juan Zhou and Jayawardana, \{Kalana W.\} and Na Kong and Yansong Ren and Nanjing Hao and Mingdi Yan and Olof Ramstr{\"o}m",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

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day = "14",

doi = "10.1021/acsbiomaterials.5b00274",

language = "英语",

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TY - JOUR

T1 - Trehalose-Conjugated, Photofunctionalized Mesoporous Silica Nanoparticles for Efficient Delivery of Isoniazid into Mycobacteria

AU - Zhou, Juan

AU - Jayawardana, Kalana W.

AU - Kong, Na

AU - Ren, Yansong

AU - Hao, Nanjing

AU - Yan, Mingdi

AU - Ramström, Olof

PY - 2015/12/14

Y1 - 2015/12/14

N2 - Glyconanoparticle carriers have been synthesized and efficiently delivered into mycobacteria. Mesoporous silica nanoparticles were functionalized with α,α-trehalose through azide-mediated surface photoligation, and loaded with the antitubercular drug isoniazid. The glyconanoparticles showed high isoniazid loading capacity and higher antimicrobial activity than the free drug.

AB - Glyconanoparticle carriers have been synthesized and efficiently delivered into mycobacteria. Mesoporous silica nanoparticles were functionalized with α,α-trehalose through azide-mediated surface photoligation, and loaded with the antitubercular drug isoniazid. The glyconanoparticles showed high isoniazid loading capacity and higher antimicrobial activity than the free drug.

KW - drug delivery

KW - isoniazid

KW - mesoporous silica nanoparticle

KW - trehalose

UR - https://www.scopus.com/pages/publications/84969257049

U2 - 10.1021/acsbiomaterials.5b00274

DO - 10.1021/acsbiomaterials.5b00274

M3 - 文章

AN - SCOPUS:84969257049

SN - 2373-9878

VL - 1

SP - 1250

EP - 1255

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

IS - 12

ER -

Trehalose-Conjugated, Photofunctionalized Mesoporous Silica Nanoparticles for Efficient Delivery of Isoniazid into Mycobacteria

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Keywords

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