Transition-metal free alkylarylation of acrylamides initiated by radical C-C bond cleavage of the tertiary cycloalkanols

Li Na Guo; Zhi Qiang Deng; Yong Wu; Jie Hu

doi:10.1039/c6ra03431d

Transition-metal free alkylarylation of acrylamides initiated by radical C-C bond cleavage of the tertiary cycloalkanols

Li Na Guo
, Zhi Qiang Deng
, Yong Wu
, Jie Hu

School of Chemistry

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

An efficient Na₂S₂O₈-promoted radical cyclization reaction of acrylamides with the tertiary cycloalkanols has been developed. This one pot procedure involves a tandem C-C bond cleavage and two C-C bonds formation process. The key advantages of this protocol are its transition-metal free, its operational simplicity and its excellent functional group tolerance, thus allowing a facile access to oxindoles containing a carbonyl group.

Original language	English
Pages (from-to)	27000-27003
Number of pages	4
Journal	RSC Advances
Volume	6
Issue number	32
DOIs	https://doi.org/10.1039/c6ra03431d
State	Published - 2016

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10.1039/c6ra03431d

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title = "Transition-metal free alkylarylation of acrylamides initiated by radical C-C bond cleavage of the tertiary cycloalkanols",

abstract = "An efficient Na2S2O8-promoted radical cyclization reaction of acrylamides with the tertiary cycloalkanols has been developed. This one pot procedure involves a tandem C-C bond cleavage and two C-C bonds formation process. The key advantages of this protocol are its transition-metal free, its operational simplicity and its excellent functional group tolerance, thus allowing a facile access to oxindoles containing a carbonyl group.",

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doi = "10.1039/c6ra03431d",

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T1 - Transition-metal free alkylarylation of acrylamides initiated by radical C-C bond cleavage of the tertiary cycloalkanols

AU - Guo, Li Na

AU - Deng, Zhi Qiang

AU - Wu, Yong

AU - Hu, Jie

PY - 2016

Y1 - 2016

N2 - An efficient Na2S2O8-promoted radical cyclization reaction of acrylamides with the tertiary cycloalkanols has been developed. This one pot procedure involves a tandem C-C bond cleavage and two C-C bonds formation process. The key advantages of this protocol are its transition-metal free, its operational simplicity and its excellent functional group tolerance, thus allowing a facile access to oxindoles containing a carbonyl group.

AB - An efficient Na2S2O8-promoted radical cyclization reaction of acrylamides with the tertiary cycloalkanols has been developed. This one pot procedure involves a tandem C-C bond cleavage and two C-C bonds formation process. The key advantages of this protocol are its transition-metal free, its operational simplicity and its excellent functional group tolerance, thus allowing a facile access to oxindoles containing a carbonyl group.

UR - https://www.scopus.com/pages/publications/84961141649

U2 - 10.1039/c6ra03431d

DO - 10.1039/c6ra03431d

M3 - 文章

AN - SCOPUS:84961141649

SN - 2046-2069

VL - 6

SP - 27000

EP - 27003

JO - RSC Advances

JF - RSC Advances

IS - 32

ER -

Transition-metal free alkylarylation of acrylamides initiated by radical C-C bond cleavage of the tertiary cycloalkanols

Abstract

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