Total synthesis of rhizopodin

Michael Dieckmann; Manuel Kretschmer; Pengfei Li; Sven Rudolph; Daniel Herkommer; Dirk Menche

doi:10.1002/anie.201201946

Total synthesis of rhizopodin

Michael Dieckmann
, Manuel Kretschmer
, Pengfei Li
, Sven Rudolph
, Daniel Herkommer
, Dirk Menche

Frontier Institute of Science and Technology

Heidelberg University
ASM Research Chemicals
University of Bonn

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Symmetry helps: The total synthesis of the potent actin-targeting C ₂-symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the convergent assembly of three building blocks of similar complexity, a concise macrocyclization strategy, and a late-stage introduction of the labile side chains.

Original language	English
Pages (from-to)	5667-5670
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	23
DOIs	https://doi.org/10.1002/anie.201201946
State	Published - 4 Jun 2012

Keywords

actin
macrolides
natural products
polyketides
total synthesis

Access to Document

10.1002/anie.201201946

Cite this

@article{4712688587384bed91e22e2f4d8bc863,

title = "Total synthesis of rhizopodin",

abstract = "Symmetry helps: The total synthesis of the potent actin-targeting C 2-symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the convergent assembly of three building blocks of similar complexity, a concise macrocyclization strategy, and a late-stage introduction of the labile side chains.",

keywords = "actin, macrolides, natural products, polyketides, total synthesis",

author = "Michael Dieckmann and Manuel Kretschmer and Pengfei Li and Sven Rudolph and Daniel Herkommer and Dirk Menche",

year = "2012",

month = jun,

day = "4",

doi = "10.1002/anie.201201946",

language = "英语",

volume = "51",

pages = "5667--5670",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "23",

}

TY - JOUR

T1 - Total synthesis of rhizopodin

AU - Dieckmann, Michael

AU - Kretschmer, Manuel

AU - Li, Pengfei

AU - Rudolph, Sven

AU - Herkommer, Daniel

AU - Menche, Dirk

PY - 2012/6/4

Y1 - 2012/6/4

N2 - Symmetry helps: The total synthesis of the potent actin-targeting C 2-symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the convergent assembly of three building blocks of similar complexity, a concise macrocyclization strategy, and a late-stage introduction of the labile side chains.

AB - Symmetry helps: The total synthesis of the potent actin-targeting C 2-symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the convergent assembly of three building blocks of similar complexity, a concise macrocyclization strategy, and a late-stage introduction of the labile side chains.

KW - actin

KW - macrolides

KW - natural products

KW - polyketides

KW - total synthesis

UR - https://www.scopus.com/pages/publications/84861634554

U2 - 10.1002/anie.201201946

DO - 10.1002/anie.201201946

M3 - 文章

C2 - 22532514

AN - SCOPUS:84861634554

SN - 1433-7851

VL - 51

SP - 5667

EP - 5670

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 23

ER -

Total synthesis of rhizopodin

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this